ISRCTN87590288已完成未知
The effect of ivabradine versus standard pharmacotherapy on hemodynamics in patients with chronic heart failure (CHF) and the analysis of the possible mechanism of improvement
Faculty Hospital Olomouc (Czech Republic)0 个研究点目标入组 50 人开始时间: 2012年1月4日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Aged more than 18 years
- •3. Left ventricular ejection fraction (LVEF) = 40%
- •4. Sinus rhythm
- •5. Patients four weeks stabile on maximal tolerated standard CHF pharmacotherapy without acute decompensations
- •6. Heart rate after 5 minutes resting more than or 70 beats per min measured by ECG
- •7. Patients indicated to Cardiac Resynchronization Therapy (CRT) will be enrolled after 6 months after implantation
- •8. Patients who give written informed consent
排除标准
- •1. Permanent atrial fibrillation with the rate control strategy
- •2. Sick sinus syndrome
- •3. Sinoatrial block or AV block of III degree without pacemaker
- •4. Patients with pacemaker/implantable cardioverter defibrillator (ICD) without CRT with more than 40% paced contractions daily
- •5. Patients less than two months after myocardial infarction (MI)
- •6. Ivabradine intolerance
- •7. Severe liver insufficiency
- •8. Combination with strong CYP3A4 inhibitors such as azol antimycotics (ketokonazol, itrakonazol), makrolid antibiotics (klarithromycin, erythromycin per os, josamycin, telithromycin), inhibitors of HIV proteases (nelfinavir, ritonavir) and nefazodon
- •9. Other illness which limits patients prognosis of less than two years
- •10. Women in fertile age without effective contraception
- •11. Breastfeeding women
研究者
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