The Role of Anterior Segment Optical Coherence Tomography in Management of Acquired Punctal Stenosis
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- punctal opening
研究概览
简要总结
This is a clinical trial study that was conducted on patients with punctal stenosis.We studied the diameter of stenosed puncta before and after treatment with preserved free steroid eye drops using AS-OCT.
详细描述
The study was conducted on 40 eyes of 24 patients have acquired inflammatory punctal stenosis and 20 eyes of 10 patients of normal asymptomatic subjects as control group. We studied the external punctal diameter, visibility of the internal punctum and punctal depth before treatment using AS-OCT, and then patients were re-evaluated after one month of treatment with preservative free methylprednisolone 5% eye drops.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients have acquired inflammatory punctum stenosis complaining of epiphora of different etiologies.
排除标准
- •Previous lacrimal surgery.
- •Lid margin malposition such as ectropion, entropion or lid retraction.
- •Medial lid masses obscuring punctum.
- •History of ocular trauma involving lid margin or punctum.
研究组 & 干预措施
Methylprednisolone eye drops
Preservative free steroids methylprednisolone 5% eye drops (prepared by dilution of methyleprednisolone 500mg in 10 ml distilled water (Solu-Medrol, Pfizer company) was prepared and given for all enrolled cases by the following regimen 5 times/day for 5 days with gradual decrease every third day over the following 2 weeks
干预措施: Methylprednisolone eyedrops (Drug)
distilled water eyedrops
Distilled water eyedrops instilled 3 times per day for two weeks
干预措施: Methylprednisolone eyedrops (Drug)
结局指标
主要结局
punctal opening
时间窗: one month
evaluation of punctalopening by OCT
次要结局
未报告次要终点
研究者
Amr Mahmoud Awara
assistant professor of ophthalmology
Tanta University