Influence of glaucoma on circadian biological rhythm
Not Applicable
- Conditions
- glaucoma
- Registration Number
- JPRN-UMIN000027299
- Lead Sponsor
- ara Medical University School of Medicine, Department of Ophthalmology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 172
Inclusion Criteria
Not provided
Exclusion Criteria
1)severe mental illness and dementia 2)severe corneal opacity and cataract 3)vitreous hemorrhage 4)severe retinal and choroidal disease
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Prevalence of circadian rhythm-related disorder (depressive symptoms, sleep disturbance and cognitive impairment) 1) Depressive symptoms (Geriatric Depression Scale:GDS) 2) Objective sleep quality (measured using actigrapgh) 3) Subjective sleep quality (Pittsburgh Sleep Quality Index:PSQI) 4) Sleepiness (Epworth Sleepiness Scale: ESS) 5) Cognitive function (Mini Mental State Examination: MMSE)
- Secondary Outcome Measures
Name Time Method 1 Ophthalmic outcomes 1) Visual acuity and intraocular pressure 2) Retinal and Choroidal thickness(OCT: optical coherence tomography) 3) OCT angiography 4) Visual field 5) ocular circulation (LSFG: Laser Speckle Flowgraphy) 6) Post Illumination Pupil Response (PIPR) 7) Contact Dermatitis 8) The 25-itemNational Eye Institute Visual Function Questionnaire (NEI VFQ-25) 2 Glucose-lipid metabolism outcomes 1) FPG HbA1c 2) TG T-chol LDL chol and HDL chol BMI(Body Mass Index) Abdominal circumference 3 Circadian rhythm outcomes 1) 6-sulfatoxymelatonin(aMT6-s)in a morning spot urine sample 2) Circadian activity rhythm 3) skin temperatures 4) ambulatory blood pressure monitoring (ABPM) 4 Vascular endothelial function Asymmetric Dimethylarginine (ADMA) 5 Neurotrophic factor Brain-derived neurotrophic factor (BDNF) 6 Residential characteristics 7 Dietary habit 8 Physical activity