Hemodynamic Adaptation to Pregnancy and Placenta-related Outcome (HAPPO study)

Completed

• Conditions: Maternal cardiovascular adaptation and utero(placental) vascular development; preeclampsia; small for gestational age; 10010273

• Registration Number: NL-OMON55842
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 300

Inclusion Criteria

1) *18 years of age
2) Delivery date of last pregnancy more than one year ago
3) Current wish to get pregnant
4) The previous pregnancy was either complicated by PPC (high-risk group) OR
the previous pregnancy was uncomplicated and resulted in a term delivery
(low-risk group).

Exclusion Criteria

1) Unable or unwilling to provide informed consent
2) Currently breastfeeding, since this may influence a woman*s vascular
condition

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome measure is the difference in maternal cardiovascular<br /><br>adaptation to pregnancy between women who do and do not develop PPC, expressed<br /><br>as the trajectory of cardiac output measured before pregnancy (preconceptional<br /><br>visit), three times during pregnancy (between 9-11, 20-22 and 30-32 weeks<br /><br>gestation) and post-delivery (3 months after giving birth).</p><br>