Healthy heart, healthy pregnancy? How a woman's periconceptional cardiovascular health affects pregnancy outcome.
Recruiting
- Conditions
- PreeclampsiaPregnancy induced hypertensionFetal growth restrictionSmall for gestational ageCardiovascular disease riskPre-eclampsie (zwangerschapsvergiftiging)Zwangerschapshypertensie (hoge bloeddruk in de zwangerschap)Foetale groeivertragingTe laag geboortegewichtCardiovasculair risicoprofiel
- Registration Number
- NL-OMON25494
- Lead Sponsor
- Erasmus MC, University Medical Center Rotterdam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 300
Inclusion Criteria
Female
- Age above 18 years old
Exclusion Criteria
- Women unable or unwilling to provide informed consent
- Women currently breastfeeding
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome measure of the HAPPO study is the difference in maternal hemodynamic adaptation to pregnancy, expressed as the trajectory of cardiac output assessed by echocardiography before, during and after pregnancy, between women who do and do not develop placenta-related pregnancy complications
- Secondary Outcome Measures
Name Time Method The secondary outcome measures are differences in additional indices of maternal hemodynamic adaptation to pregnancy and utero(placental) vascular development between women who do and do not develop placenta-related pregnancy complications. <br>This includes differences in weight gain during pregnancy, blood pressure, systemic vascular resistance, left ventricular diastolic function, endothelial regulated microvascular function, pulse wave analysis, hemodynamic response to exercise, placental vascular indices, foetal growth parameters (including Doppler measurements) and placenta/placental bed pathology examinations.