11C-PIB PET Study in the Multi Ethnic Study of Atherosclerosis at Columbia University
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 59
- 试验地点
- 1
- 主要终点
- Whole Brain 11C-PIB SUVR
研究概览
简要总结
The investigators will conduct a study of brain positron emission tomography (PET) using 11C-PIB for the imaging of brain amyloid in 250 participants in the Multiethnic study of atherosclerosis (MESA) at Columbia University Irving Medical Center in New York City. Participants will be imaged only once with Pittsburgh Compound B (PIB) PET.
详细描述
This is a single center PET study of 11C-PIB. Eligible participants are current participants in the MESA study in New York City, without contraindications to MRI or PET procedures. Those eligible will have one brain PET scan with 11C-PIB within 12 months of a brain MRI. Vital signs will be checked prior to injection of 11C-PIB, 10 minutes after the injection, and again at the completion of the PET scan. The primary outcome measure for amyloid will be whole brain 11C-PIB SUVR. The relation between exposure groups and amyloid in the brain will be analyzed using linear regression.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Current participants in MESA study at Columbia University
- •60 years or older
- •Fluent in English and/or Spanish.
- •Able to participate in all scheduled evaluations and to complete all required tests and procedures.
排除标准
- •Active treatment for cancer
- •Any serious medical condition which would prevent long-term participation
- •Pregnancy
- •Weight >300 pounds
- •Participants previously diagnosed or adjudicated to have dementia
- •Participants unwilling to undergo cognitive testing
- •Plans to leave the community within five years
- •Language barrier (speaks other than English, Spanish, Chinese)
- •Inability to give informed consent or to obtain consent from a Legally Authorized Representative (LAR)
研究组 & 干预措施
MESA study participants
Current participants in the MESA study in New York City, 60 years or older, fluent in English or Spanish, able to participate in the brain imaging study
干预措施: 11C-PIB (Drug)
结局指标
主要结局
Whole Brain 11C-PIB SUVR
时间窗: 40 to 90 minutes post injection
Standardized uptake value ratio (SUVR) of 11C-PIB;The extent of Aβ deposition in the brain will be quantified by\[11C\]PiB uptake visualized by PET using standardized uptake volume ratio (SUVR) of 6 primary cortical areas (i.e., anterior cingulate, prefrontal cortex, lateral temporal cortex, posterior parietal cortex, precuneus cortex, and anteroventral striatum) relative to the uptake in the cerebellum
次要结局
未报告次要终点
研究者
José A. Luchsinger
Associate Professor of Medicine
Columbia University