Is Lipoprotein-a Just a Lipid Marker or a Predictor for the Severity of Coronary Lesions in Aortic Valve Sclerosis Patients?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Incidence of significance of coronary lesions
研究概览
简要总结
This work aimed to evaluate the association of serum level of Lp(a) with the severity of coronary artery disease (CAD) in aortic valve sclerosis (AVS) patients.
详细描述
Aortic valve sclerosis (AVS) has a prevalence of 2% to 7% in the population above 65 years of age. In industrialized countries, aortic valve sclerosis is most frequently caused by progressive calcification and degeneration of the aortic cusps.
Coronary artery disease (CAD) is the most significant single cause of death in the world. In developed countries, more than 25% of all deaths in persons older than 35 years are due to CAD. More than half of acute myocardial infarctions occur without previous history or symptoms of CAD.
In recent years, there has been a special emphasis on lipoprotein(a) (Lp(a)), a significant, causal, and nonmodifiable predictor of valvular outcomes and CAD in the general population
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years.
- •Both sexes.
- •Patients with chest pain and/or dyspnea were diagnosed provisionally as having coronary artery disease.
排除标准
- •Aortic stenosis.
- •Aortic prosthesis.
- •Untreated hypothyroidism.
- •Severe chronic kidney failure.
- •Administration of anti-inflammatory or immunosuppressive drugs.
- •Pregnancy.
结局指标
主要结局
Incidence of significance of coronary lesions
时间窗: 1 month post-procedure
Incidence of significance of coronary lesions in relation to lipoprotein (a) level was recorded.
次要结局
未报告次要终点
研究者
Remon Saleh Adly
Lecturer of Cardiovascular, Faculty of Medicine, Sohag University, Sohag, Egypt.
Sohag University