Coagulation Effect of Anesthesia
Not Applicable
Completed
- Conditions
- Changes in coagulation during induction of anesthesia in elective surgery: cholecystectomySurgery
- Registration Number
- ISRCTN15932456
- Lead Sponsor
- inköping University Hospital (Sweden)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
1. Patients over the age of 18, belonging to American Society of Anaesthesiologists (ASA) physical status classification score groups I and II
2. Patients operated with cholecystectomy
3. Patients signing informed consent after oral and written information
Exclusion Criteria
1. Regional anesthesia
2. Age less than 18 years
3. Pregnancy
4. ASA group III and IV
5. Cardiac disease
6. Known kidney failure (creatinine >170)
7. Rheumatoid arthritis
8. Treatment with anticoagulants
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Qualitative analysis of blood clotting by rotational trombelastometry (ROTEM). Blood samples are collected prior to anesthesia and 15 minutes after induction of anesthesia.
- Secondary Outcome Measures
Name Time Method <br> All other clotting tests performed before and 15 minutes after induction of anesthesia:<br> 1. Hemoglobin (Hgb)<br> 2. Albumin<br> 3. Thrombin antthrombin complex (TAT)<br> 4. D-dimer<br> 5. Soluble P-selectin<br> 6. Activated partial thrombin time (APTT)<br> 7. Prothrombin time (PT) and international normalized ratio (INR)<br> 8. Platelets<br>