Effect of Tranexamic Acid on Intra-Operative Blood Loss in Brain Tumor Resection Surgery
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- To study the effect of Tranexamic acid (TXA) on the intra-operative blood loss during tumor resection surgery.
研究概览
简要总结
•Intracranial tumor excision can be associated with major blood loss and require transfusion of large volumes of blood and blood products .
•The Intra-operative blood loss is in turn directly related to the post-operative morbidity and mortality
•Tranexamic Acid (TXA) is a synthetic derivative of the amino acid lysine that acts as an antifibrinolytic, is largely used to reduce the blood loss .
•Administration of Tranexamic acid (TXA) , has resulted in survival benefits in Traumatic Brain Injury (TBI) patients ,by reducing blood loss as per recent studies
In this study , we aim to study the effect of Tranexamic acid (TXA) in reduction of intra-operative blood loss.
•Aim is to study the effect of Tranexamic acid(TXA) on Intra –operative Blood Loss during Brain Tumor Resection Surgery
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •All patients diagnosed with brain tumor who will undergo tumor resection surgery after admission Age group 18 – 65 years Patient without any history of coagulopathy.
排除标准
- •Patient having hypersensitivity to Tranexamic acid Patients with known contraindications to antifibrinolytic agents Patients with thromboembolic events.
- •Patients with abnormal liver function.
结局指标
主要结局
To study the effect of Tranexamic acid (TXA) on the intra-operative blood loss during tumor resection surgery.
时间窗: Base line post induction and continuous intra operative Blood Loss assessment at 30 minute interval
次要结局
未报告次要终点
研究者
Dr Pushkar Ranjan
heritage institute of medical sciences