Efficacy of Highly Selective-a-1A-Adrenoceptor AntagonistSilodosin in Expulsive Therapy of Lower Ureteral Stones:A Randomized Controlled Study
Phase 4
Recruiting
- Conditions
- radiopaque lower ureteral stones >5mmRenal and Urogenital - Other renal and urogenital disorders
- Registration Number
- ACTRN12611000571976
- Lead Sponsor
- Chung Jing Wang
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
symptomatic radiopaque lower ureteral stones >5mm aged between 20 and 60 years old
Exclusion Criteria
Subjects with urinary tract infections, high-grade hydronephrosis, diabetes, ulcers, or a history of hypersensitivity toa-1 blocker and pregnant women were excluded. Patients with a history of spontaneous stone expulsion, hypotension, or those found to have systolic blood pressure lower than 110 mmHg were also excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method expulsion time[reported by patient diaries or Stone presence and characteristics were diagnosed through x-ray of kidney-ureter-bladder, abdominal ultrasonography, intravenous urography and nonenhenced CT at 2 weeks.];expulsion rate[Stone presence and characteristics were diagnosed through x-ray of kidney-ureter-bladder, abdominal ultrasonography, intravenous urography and nonenhenced CT at 2 weeks.]
- Secondary Outcome Measures
Name Time Method analgesic consumption[recorded by patient(All patients were prescribed ketorolac 10 mg three time per day for analgesic use and allowed to use sublingual buprenorphine 0.2 mg on demand) at 2 weeks];lower urinary tract symptoms[IPSS questionnaire at 2 weeks];colic episodes[recorded by patient diaries daily for 2 weeks];adverse effects[dizziness,postural hypotension by patient diaries daily for 2 weeks]