Relevance of Sensitization to Fenugreek in Children

• Conditions: Allergy to Fenugreek

• Registration Number: NCT05340920
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

The prevalence of allergy to legumes is inscreasing, especially in children and for some of these legumes, little is known and there are not included in the list of priority allergen. The overall goal of this study is to improve knowledge about fenugreek allergy. The principal aim is to evaluate the prevalence of allergy to fenugreek confirmed by a positive oral food challenge in children sensitized to fenugreek. The secondary objectives are to describe the case of allergy to fenugreek (co-allergies, severity, age..), to evaluate diagnostic values of skin prick-tests and specific IgE and to compare the molecular profile of specific IgE to peanut between sensitization to fenugreek without allergy and sensitization with a confirmed allergy

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-04
• Study Start: 2022-04
• Study First Submitted: 2022-04-08
• Study First Submitted QC: 2022-04-15
• Last Update Submitted: 2022-04-15
• Study First Posted: 2022-04-22
• Last Update Posted: 2022-04-22
• Primary Completion: 2022-05
• Study Completion: 2022-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Children for whom an oral food challenge to fenugreek has been performed between the 1st January 2017 and the 15th April 2022 and for whom skin prick test and/or specific IgE to fenugreek are avalaible

Exclusion Criteria

• patient over 18 years old
• undeterminate oral food challenge

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Oral food challenge to fenugreek	2017-2022	Astier's score 0 to 4 (0=negative, 1 and 2=mild to moderate reaction, 3 and 4 = severe reaction)
skin prick-test to fenugreek	2017-2022	skin prick test positive if wheal size superior to 3mm
specific IgE to fenugreek	2017-2022	specific IgE positive if value superior to 0.35kU/L

Secondary Outcome Measures

Name	Time	Method
severity of allergy	2017-2022	reactogenic dose (from 1 to 1000mg of fenugreek)
molecular profile for peanut allergy	2017-2022	IgE values for rAra h1, h2, h3, h6, h8, h9

Trial Locations

Locations (1)

Centre Hospitalo-Universitaire de Nancy; 🇫🇷 Vandœuvre-lès-Nancy, France