Accidental Reactions in Peanut/Tree Nut Allergic Children

Recruiting

• Conditions: Peanut and Tree Nut Allergy

• Registration Number: NCT05671471
• Lead Sponsor: University Hospital, Lille

Brief Summary

Food allergy is an immune reaction, triggered by food protein allergens, of varying severity, from mild local reaction to life threatening anaphylaxis and fatalities.

Peanut is a plant from the botanical family of the Fabaceae, more commonly known as legumes. The prevalence of peanut and tree nut allergy is increasing. In France (ELFE cohort), it is estimated to 0.93%. The tree nuts include mainly almond, hazelnut, pistachio, cashew nut, walnut, pecan nut and Brazil nut. Allergy's prevalence is estimated to 0.54% in children up to 5.5 years. Peanut allergy is a main cause of anaphylaxis and deaths due to food allergy.

Recurrence of food allergy is a main concern. The risk has been estimated to 10% per year for peanut.

In France, Data in real-life on the rate of recurrence of allergic reactions and anaphylaxis to peanut/tree-nut as well as risk factors, are lacking.

The objective of this study is to assess the frequency of allergic reaction to peanut and tree-nuts, to describe the reactions' characteristics and risk factors.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-22
• Status Verified: 2022-11
• Study First Submitted: 2022-11-03
• Study First Submitted QC: 2023-01-02
• Last Update Submitted: 2023-01-02
• Study First Posted: 2023-01-04
• Last Update Posted: 2023-01-04
• Primary Completion: 2023-09
• Study Completion: 2023-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Confirmed allergy to peanuts and/or nuts

Exclusion Criteria

• Other chronic diseases, except allergic comorbidities (asthma, rhinitis, atopic dermatitis, other food allergy)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the number of episode of allergic reactions in real life	At 1 year

Secondary Outcome Measures

Name	Time	Method
the severity of the allergic reactions according to a validated scale (FASS scale)	At 1 year
interview for the characteristics of the allergic reactions	At 1 year	the characteristics of the reactions: symptoms, triggering food and quantity, location, emergency kit available, treatment administered, evolution (hospitalization or emergency room)
interview to defined the risks factor associated	At 1 year	risk factors for reaction: * Other known allergies; * Asthma; * Atopic dermatitis; * Allergic rhinoconjunctivitis; * Patient characteristics: sex, age

Trial Locations

Locations (1)

Hop Jeanne de Flandre Chu Lille; 🇫🇷 Lille, France