Deep Brain Stimulation for the Treatment of Major Depressive Disorder

Monash Alfred Psychiatry Research Centre0 个研究点目标入组 8 人开始时间: 2013年4月15日最近更新: 2021年6月14日

适应症

试验速览

暂无简介。

•Patients will be included if they:
•1. Have a DSM-IV diagnosis of a major depressive episode as confirmed by interview using the Structured Clinical Interview for DSM IV and review by two independent psychiatrists,
•2.Age 18-70 years,
•3. Have treatment resistant depression at Stage V of the Thase and Rush classification. This requires failure to respond to adequate courses of at least several different classes of antidepressants and a course of bilateral ECT. We will require patients to have failed to respond to trials of medications from all classes, ECT and cognitive behavioural therapy.
•4.Have been depressed for a minimum of three years and have a Montgomery-Asberg Depression Rating Scale score of > 25 (moderate – severe depression),
•5. Demonstration of capacity to give informed consent: this will be thoroughly assessed and documented by two independent psychiatrists and a neuropsychologist and via signing of the consent form.

•Patients who:
•1. Have an unstable medical condition, neurological disorder or any history of a seizure disorder or are currently pregnant or lactating,
•2.Significant concurrent Axis I or II psychiatric morbidity,
•3.No evidence of substantive premorbid functioning after the age of 20 and within the last 15 years, including capacity to engage in prolonged relationships and meaningful functional activities (work, study, home-care).

发起方

Monash Alfred Psychiatry Research Centre