Deep Brain Stimulation in the Treatment of Depressio

Not Applicable

• Conditions: Major Depressive Disorder; Mental Health - Depression

• Registration Number: ACTRN12613000412730
• Lead Sponsor: Monash Alfred Psychiatry Research Centre

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-04-15
• Study Completion: 2020-08-05
• Last Update Posted: 14 June 2021

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

Patients will be included if they:

1. Have a DSM-IV diagnosis of a major depressive episode as confirmed by interview using the Structured Clinical Interview for DSM IV and review by two independent psychiatrists,

2.Age 18-70 years,

3. Have treatment resistant depression at Stage V of the Thase and Rush classification. This requires failure to respond to adequate courses of at least several different classes of antidepressants and a course of bilateral ECT. We will require patients to have failed to respond to trials of medications from all classes, ECT and cognitive behavioural therapy.

4.Have been depressed for a minimum of three years and have a Montgomery-Asberg Depression Rating Scale score of > 25 (moderate – severe depression),

5. Demonstration of capacity to give informed consent: this will be thoroughly assessed and documented by two independent psychiatrists and a neuropsychologist and via signing of the consent form.

Exclusion Criteria

Patients who:
1. Have an unstable medical condition, neurological disorder or any history of a seizure disorder or are currently pregnant or lactating,

2.Significant concurrent Axis I or II psychiatric morbidity,

3.No evidence of substantive premorbid functioning after the age of 20 and within the last 15 years, including capacity to engage in prolonged relationships and meaningful functional activities (work, study, home-care).

Study & Design

• Study Type: Interventional
• Study Design: Not specified