Does Statin Therapy Reduce Sympathoexcitation in Hypertension?

Not Applicable

Completed

• Conditions: Hypertension

• Registration Number: NCT00497016
• Lead Sponsor: Radboud University Medical Center

Brief Summary

A number of patients with hypertension have increased central sympathetic activity. Statins seem to inhibit central sympathetic output. This study assesses the effect of statins on central sympathetic activity in hypertension patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-05
• Study First Submitted: 2007-07-04
• Study First Submitted QC: 2007-07-04
• Study First Posted: 2007-07-06
• Study Completion: 2008-03
• Status Verified: 2008-09
• Last Update Submitted: 2008-09-29
• Last Update Posted: 2008-09-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

• (Known) hypertension
• stable drug therapy for at least 2 months
• age 18-70 jaar
• BMI 18-35 kg/m2
• Sinusrhythm

Exclusion Criteria

• Recent cardiovascular event <6 mnd
• Plasma Creatinin:
• female: >120 mmol/L
• male: >133 mmol/L
• use of:
• tricyclic antidepressants
• alpha-1 -and/or alpha-2 blockers
• disease of the autonomic nervous system (Parkinsons disease, Shy- Drager syndrome, etc)
• Albuminuria >300 mg/dag

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
change in central sympathetic activity

Secondary Outcome Measures

Name	Time	Method
change in cholesterol levels, renin and aldosteron

Trial Locations

Locations (1)

Radboud University Medical Center Nijmegen; 🇳🇱 NIjmegen, Netherlands