Effect of Statins on Sympathetic Activity in Hypertensive Patients with Chronic Kidney Disease: a Randomized trial in Hypertensive Patients with Chronic Kidney Disease

Phase 3

Completed

• Conditions: Hypertensie; chronic kidney disease; Chronic renal diseases; 10029149

• Registration Number: NL-OMON33524
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Patients older than 18 years old with stable chronic kidney disease and hypertension using an ACE inhibitor or an ARB are included in this project.

Exclusion Criteria

Patients with diabetes mellitus, patients on renal replacement therapy, preganant patients and patients on antihypertensive medication (which cannot be stopped) are excluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary endpoint<br /><br><br /><br>- the effect of atorvastatin 20mg/day added on standard antihypertensive<br /><br>treamten (ARB) on MSNA<br /><br><br /><br>Primay outcome:<br /><br><br /><br>- a substantial decrease in MSNA after 6 weeks treatment with atorvastatin<br /><br>added on standard antihypertensive treatment (ARB)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Effect of atorvastatin 20mg/day on plasma renin activity and kidney function.<br /><br><br /><br><br /><br>Secondary outcome:<br /><br><br /><br>-We expect no or little effect on heart rate, inhibition of plasma renin<br /><br>activity and no effect on kidney function. </p><br>