Improved efficacy of seasonal influenza vaccination in the elderly orally receiving Mekabu fucoidan from edible seaweed: a randomised placebo controlled trial

Not Applicable

• Conditions: influenza

• Registration Number: JPRN-UMIN000006394
• Lead Sponsor: Institute for World Health Development, Mukogawa Women's University

Brief Summary

Efficacy of influenza vaccines was improved by the administration of Mekabu fucoidan (MF). Particularly in response to B type influenza virus, the efficacy of vaccination was proved only in MF group, but not in placebo group. The efficacy was marked in the individuals whose antibody titer was lower (< 1:10). The efficacy improvement by MF was proven against all types of influenza vaccination. 14th International Congress Immunology Aug, 26, 2010

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2010-03-01
• Study Start: 2011-09-22
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Not provided

Exclusion Criteria

1.Those who were taking any drugs or supplements affecting immunological response. 2.Those who suffered from severe forms of rheumatoid arthritis 3.Those who had allergy against seaweeds and other dietary components. 4.These who were judged not to be appropriate for the study by a responsible doctor.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Influenza vaccination titer

Secondary Outcome Measures

Name	Time	Method
K-cell activity, IgA, IgG