Sex- and Context-dependent Effects of Oxytocin on Social Reward Processing
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 252
- 试验地点
- 1
- 主要终点
- fMRI: neural activity during social reward processing
研究概览
简要总结
The aim of the present study is to examine whether the neuropeptide oxytocin (OXT) influences social reward processing and whether the effects are context- and sex-dependent.
详细描述
In a double-blind, randomized, placebo-controlled, between-subject design healthy volunteers will receive either oxytocin or placebo nasal spray (40IU in 10 puffs).
Subjects will come to the experiment in pairs (two friends of the same sex). 45 min after drug administration, the two subjects will simultaneously undergo a social reward task - during the task, functional magnetic resonance imaging (fMRI) data will be acquired from one of them. During the social reward task subjects will be asked to rate the valence and arousal of emotional pictures in three different conditions: alone, share with a stranger and share with their friend.
Before treatment, subjects will complete a range of validated questionnaires to control for potential confounders, such as level of depression (assessed using the BDI) and to explore associations between relevant personality factors and treatment effects, such as adult attachment style (assessed using the AAS).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 17 Years 至 30 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects without past or current psychiatric or neurological disorder, right-handed, had normal or corrected-to normal vision.
排除标准
- •self-reported medication use, substance abuse, and presence of medical or psychiatric disorders
研究组 & 干预措施
Oxytocin
Oxytoxin nasal spray
干预措施: Oxytocin (Drug)
Placebo
Placebo nasal spray
干预措施: Placebo (Drug)
结局指标
主要结局
fMRI: neural activity during social reward processing
时间窗: 45-115 minutes after administration
Main effects of treatment will be analyzed on fMRI activity during a social reward processing paradigm.
Modulatory effects of sex on fMRI based neural indices during social reward processing
时间窗: 45-115 minutes after administration
Interaction between treatment effects and sex will be analyzed on fMRI indices acquired during reward processing
fMRI: functional connectivity during social reward processing
时间窗: 45-115 minutes after administration
Main effects of treatment will be analyzed on fMRI connectivity during a social reward processing paradigm.
次要结局
- Behavior: arousal ratings during social reward processing(45-115 minutes after administration)
- Behavior: valence rating during social reward processing(45-115 minutes after administration)
- Modulatory effects of sex on arousal ratings during social reward processing(45-115 minutes after administration)
- Modulatory effects of sex on valence ratings during social reward processing(45-115 minutes after administration)
- Pre-treatment modulators: attachment style (AAS)(45-115 minutes after administration)