A study to compare the effectiveness of intravenous oxytocin with intramuscular oxytocin given at the third stage of labour at preventing bleeding at vaginal birth
- Conditions
- Postpartum haemorrhage following vaginal deliveryPregnancy and Childbirth
- Registration Number
- ISRCTN14718882
- Lead Sponsor
- Coombe Women and Infants University Hospital
- Brief Summary
2017 protocol in: https://www.ncbi.nlm.nih.gov/pubmed/29141679 2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/30181338 [added 20/03/2019]
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 1000
1. Aged 18 or over
2. Female participants only
3. Singleton pregnancy at more than 36 weeks gestation
4. Those anticipated to have a vaginal delivery
1. Women who opted for physiological management of the third stage of labour
2. Those who have an antenatal decision for 40IU oxytocin infusion prophylactically following a vaginal delivery
3. Those whom the clinician has a preferred route of administering prophylactic oxytocin for the third stage of labour
4. Those who are deemed to be at risk of postpartum haemorrhage - Previous history of atonic primary postpartum haemorrhage, multiple fibroids, coagulation disorders, thrombocytopenia and receiving anticoagulants
5. Those with previous cardiovascular disorder
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of primary postpartum haemorrhage (> 500ml) following intramuscular oxytocin compared with intravenous oxytocin is determined by reviewing participant’s medical notes and data collected in a case report form (CRF) 24 hours post-delivery.
- Secondary Outcome Measures
Name Time Method