Prevention of Remifentanil-induced Postoperative Hyperalgesia With Intravenous Ibuprofen
Overview
- Phase
- Not Applicable
- Intervention
- high dose remifentanil
- Conditions
- Ibuprofen
- Sponsor
- Seoul National University Hospital
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- cumulative morphine consumption
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
Postoperative hyperalgesia has been reported after intraoperative administration of small or high-dose remifentanil. Cyclooxygenase inhibitor exhibit preventive effects on the development of opioid-induced hyperalgesia. The aim of this study is to evaluate the preventive effect of intravenous ibuprofen (Caldolor®) on remifentanil-induced hyperalgesia
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adult patients scheduled for elective pancreaticoduodenectomy
Exclusion Criteria
- •Patients with chronic pain
- •Patients with psychiatric disease
- •Patients with nonsteroidal antiinflammatory drugs allergy
- •Patients with renail dysfunction
- •History of drug addiction
- •Pregnant patient
- •Inability to use a PCA device
Arms & Interventions
high dose remifentanil without ibuprofen
remifentanil target-controlled infusion effect-site concentration 4 ng/ml normal saline before surgical incision
Intervention: high dose remifentanil
low dose remifentanil without ibuprofen
remifentanil target-controlled infusion effect-site concentration 1 ng/ml normal saline before surgical incision
Intervention: low dose remifentanil
high dose remifentanil with ibuprofen
remifentanil target-controlled infusion effect-site concentration 4 ng/ml Intravenous ibuprofen 800 mg before surgical incision
Intervention: high dose remifentanil
high dose remifentanil with ibuprofen
remifentanil target-controlled infusion effect-site concentration 4 ng/ml Intravenous ibuprofen 800 mg before surgical incision
Intervention: Ibuprofen
low dose remifentanil with ibuprofen
remifentanil target-controlled infusion effect-site concentration 1 ng/ml Intravenous ibuprofen 800 mg before surgical incision
Intervention: Ibuprofen
low dose remifentanil with ibuprofen
remifentanil target-controlled infusion effect-site concentration 1 ng/ml Intravenous ibuprofen 800 mg before surgical incision
Intervention: low dose remifentanil
Outcomes
Primary Outcomes
cumulative morphine consumption
Time Frame: postoperative 48 hours
cumulative patient-controlled analgesia (PCA) morphine consumption
Secondary Outcomes
- Pain score(postoperative 1, 3, 6,12, 24, 48 hours Pain score)