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Clinical Trials/JPRN-UMIN000016426
JPRN-UMIN000016426
Completed
未知

Dose high dose remifentanil induce postoperative hyperalgesia? - remifentanil induced hyperalgesia

Dept. of dental anesthesia and pain management, Tohoku Univ. Hosp.0 sites52 target enrollmentMarch 1, 2015
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Conditionspostoperative pain

Overview

Phase
未知
Intervention
Not specified
Conditions
postoperative pain
Sponsor
Dept. of dental anesthesia and pain management, Tohoku Univ. Hosp.
Enrollment
52
Status
Completed
Last Updated
2 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

Remifentanil is associated with acute opioid tolerance that can lead to increased postoperative consumption of opioid analgesics. The purpose of this study was to determine whether a low dose of ketamine prevents remifentanil-induced acute opioid tolerance and affects the neutrophil-lymphocyte ratio (NLR), a newly recognized biomarker of in ambition. High-dose intraoperative remifentanil induced postoperative acute opioid tolerance that was prevented by infusion of low-dose ketamine. Ketamine increased the postoperative NLR associated with decreased fentanyl requirement for postoperative pain control.

Registry
who.int
Start Date
March 1, 2015
End Date
March 31, 2018
Last Updated
2 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
Dept. of dental anesthesia and pain management, Tohoku Univ. Hosp.

Eligibility Criteria

Inclusion Criteria

  • Not provided

Exclusion Criteria

  • •intracranial hypertension taking pain killer mental disease alcoholism

Outcomes

Primary Outcomes

Not specified

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