Postoperative Drip-infusion of Remifentanil for Preventing Remifentanil-induced Hyperalgesia- a Retrospective Observative Study
Overview
- Phase
- Not Applicable
- Intervention
- remifentanil
- Conditions
- Hyperalgesia
- Sponsor
- Tri-Service General Hospital
- Enrollment
- 559
- Locations
- 1
- Primary Endpoint
- comparison of the numeric rating scale (NRS) between 2 groups
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The development of remifentanil-induced hyperalgesia (RIH) is an unpleasant experience for surgical patients. An alternative management, gradual withdrawal of remifentanil was effective in prevention of RIH. The investigators designed a simple modality to assess if under withdrawal of remifentanil and further drip-infusion of remifentanil immediately after extubation affected postoperative pain score, the requirement of rescue analgesics, and adverse effects.
Detailed Description
In clinical practice, the gradual withdrawal of remifentanil during surgery is unsatisfied. Thus, the investigators conducted a simple modality in a single center retrospective cohort study to assess how under baseline gradual withdrawal of remifentanil and further drip infusion of remifentanil immediately after extubation affected postoperative pain score and use of analgesics.
Investigators
Yi-hsuan Huang
Principal Investigator
Tri-Service General Hospital
Eligibility Criteria
Inclusion Criteria
- •American Society of Anesthesiologists (ASA) score of I-III patients receiving total intravenous anesthesia
Exclusion Criteria
- •The use of inhalation agents or propofol combined with inhalation anesthesia
- •Pregnancy
- •Previous substance abuse
- •Known allergies to opioids, propofol or any drugs used in the study
- •History of neuropsychiatric disorder
- •Age \< 20 years or \> 80 years
Arms & Interventions
gradual withdrawal following by drip-infusion of remifentanil
In the end of the surgery, gradual withdrawal of remifentanil was prescribed until the endotracheal tube was extubated. Following by drip-infusion of remifentanil for 30 minutes was administered immediately after tracheal extubation.
Intervention: remifentanil
Outcomes
Primary Outcomes
comparison of the numeric rating scale (NRS) between 2 groups
Time Frame: one hour
NRS scores is labeled from zero to ten, with zero being an example of someone with no pain and ten being the worst pain possible.
requirement for rescue analgesics
Time Frame: one hour
postoperative requirement for rescue analgesics
Secondary Outcomes
- type of surgery(three hours)
- surgical site(three hours)