Adoption of Novel Heart Failure Therapy and Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Novartis
- 入组人数
- 42,494
- 试验地点
- 1
- 主要终点
- Time Spent 30 Days Post-discharge by Discharge Sacubitril/Valsartan (SAC/VAL) Prescription Status
研究概览
简要总结
This was a retrospective observational cohort study using patient data from the Get With The Guideline-Heart Failure (GWTG-HF) registry linked to Medicare Fee-for-Service (FFS) claims. The main goal of the study was to compare home-time in Medicare FFS patients with heart failure with mildly reduced or preserved ejection fraction discharged with sacubitril/valsartan versus those discharged without sacubitril/valsartan.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Time Spent 30 Days Post-discharge by Discharge Sacubitril/Valsartan (SAC/VAL) Prescription Status
时间窗: Post-discharge at Day 30
Time spent included home-time days, hospital days, skilled nursing facility days, rehab days, other institutional days, and death days. Home-time was defined as the number of days alive and out of the hospital, skilled nursing facility or inpatient rehabilitation facility. SAC/VAL prescription status: with SAC/VAL prescription and without SAC/VAL prescription.
Time Spent 90 Days Post-discharge by Discharge SAC/VAL Prescription Status
时间窗: Post-discharge at Day 90
Time spent included home-time days, hospital days, skilled nursing facility days, rehab days, other institutional days, and death days. Home-time was defined as the number of days alive and out of the hospital, skilled nursing facility or inpatient rehabilitation facility. SAC/VAL prescription status: with SAC/VAL prescription and without SAC/VAL prescription.
Time Spent 180 Days Post-discharge by Discharge SAC/VAL Prescription Status
时间窗: Post-discharge at Day 180
Time spent included home-time days, hospital days, skilled nursing facility days, rehab days, other institutional days, and death days. Home-time was defined as the number of days alive and out of the hospital, skilled nursing facility or inpatient rehabilitation facility. SAC/VAL prescription status: with SAC/VAL prescription and without SAC/VAL prescription.
Time Spent 365 Days Post-discharge by Discharge SAC/VAL Prescription Status
时间窗: Post-discharge at Day 365
Time spent included home-time days, hospital days, skilled nursing facility days, rehab days, other institutional days, and death days. Home-time was defined as the number of days alive and out of the hospital, skilled nursing facility or inpatient rehabilitation facility. SAC/VAL prescription status: with SAC/VAL prescription and without SAC/VAL prescription.
次要结局
- Number of All-cause Mortality Patients at 30, 90, 180, and 365 Days After Discharge With a Sacubitril/Valsartan (SAC/VAL) Prescription(Post-discharge at Days 30, 90, 180, and 365)
- Number of All-cause Mortality Patients at 30, 90, 180, and 365 Days After Discharge Without a SAC/VAL Prescription(Post-discharge at Days 30, 90, 180, and 365)
- Number of All-cause Mortality or Heart Failure (HF) Hospitalization Patients at 30, 90, 180, and 365 Days After Discharge With a SAC/VAL Prescription(Post-discharge at Days 30, 90, 180, and 365)
- Number of All-cause Mortality or HF Hospitalization Patients at 30, 90, 180, and 365 Days After Discharge Without a SAC/VAL Prescription(Post-discharge at Days 30, 90, 180, and 365)
- Number of All-cause Hospitalization Patients at 30, 90, 180, and 365 Days After Discharge With SAC/VAL Prescription(Post-discharge at Days 30, 90, 180, and 365)
- Number of All-cause Hospitalization Patients at 30, 90, 180, and 365 Days After Discharge Without a SAC/VAL Prescription(Post-discharge at Days 30, 90, 180, and 365)
- Number of Patients Hospitalized for HF at 30, 90, 180, and 365 Days After Discharge With a SAC/VAL Prescription(Post-discharge at Days 30, 90, 180, and 365)
- Number of Patients Hospitalized for HF at 30, 90, 180, and 365 Days After Discharge Without a SAC/VAL Prescription(Post-discharge at Days 30, 90, 180, and 365)
- Number Patients Hospitalized for Dialysis or End-Stage Kidney Disease at 365 Days After Discharge With and Without a SAC/VAL Prescription(Post-discharge at Day 365)
- Number Patients Hospitalized for a Metabolic/Nutritional Disorder at 365 Days After Discharge With and Without a SAC/VAL Prescription(Post-discharge at Day 365)
- Number Patients Hospitalized for Urinary Tract Infection at 365 Days After Discharge With and Without a SAC/VAL Prescription(Post-discharge at Day 365)
- Number Patients Hospitalized for a Hip Fracture at 365 Days After Discharge With and Without a SAC/VAL Prescription(Post-discharge at Day 365)
- Difference in Days of Home-time Between Discharge With and Without SAC/VAL Prescription(Post-discharge at Days 30, 90, 180, and 365)
- Difference in All-cause Mortality Between Discharge With and Without SAC/VAL Prescription(Post-discharge at Days 30, 90, 180, and 365)
- Difference in Composite Measure Between Discharge With and Without SAC/VAL Prescription(Post-discharge at Days 30, 90, 180, and 365)
- Difference in All-cause Re-hospitalization Between Discharge With and Without SAC/VAL Prescription(Post-discharge at Days 30, 90, 180, and 365)
- Difference in HF Re-hospitalization Between Discharge With and Without SAC/VAL Prescription(Post-discharge at Days 30, 90, 180, and 365)
- Difference in Hospitalization for Metabolic/Nutritional Disorder Between Discharge With and Without SAC/VAL Prescription(Post-discharge at Day 365)
- Difference in Hospitalization for Urinary Tract Infection Between Discharge With and Without SAC/VAL Prescription(Post-discharge at Day 365)
- Difference in Hospitalization for Hip Fracture Between Discharge With and Without SAC/VAL Prescription(Post-discharge at Day 365)
- Number of All-cause Re-hospitalizations per Patient by Discharge SAC/VAL Prescription Status(Post-discharge at Day 365)
- Number of HF Re-hospitalizations per Patient by Discharge SAC/VAL Prescription Status(Post-discharge at Day 365)
- All-cause Re-hospitalization Length of Stay by Discharge SAC/VAL Prescription Status(Post-discharge at Day 365)
- All-cause HF-related Re-hospitalization Length of Stay by Discharge SAC/VAL Prescription Status(Post-discharge at Day 365)