A Dose-Escalation Study of RO5126766 in Patients With Advanced Solid Tumors.

Phase 1

Completed

• Conditions: Neoplasms
• Interventions: Drug: RO5126766

• Registration Number: NCT00773526
• Lead Sponsor: Hoffmann-La Roche

Brief Summary

This study will determine the maximum tolerated dose and the dose limiting toxicities (Part 1 of study) and the activity (Part 2 of study) of RO5126766 in patients with metastatic or advanced solid tumors. In the first part of the study, groups of patients will by sequentially enrolled to receive ascending oral doses of RO5126766 daily for 28 days. The starting dose of 0.1mg will be escalated in subsequent groups of patients after a successful assessment of the safety and tolerability of the previous dose. In Part 2 of the study, patients with selected tumor types will be randomized to receive either the optimal biological dose or the maximum tolerated dose of RO5126766 daily. The anticipated time on study treatment is until disease progression, and the target sample size is 100 individuals.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Study First Submitted: 2008-10-15
• Study First Submitted QC: 2008-10-15
• Study First Posted: 2008-10-16
• Study Start: 2008-11
• Primary Completion: 2011-09
• Study Completion: 2011-09
• Status Verified: 2016-11
• Last Update Submitted: 2016-11-01
• Last Update Posted: 2016-11-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

• adult patients, >=18 years of age;
• advanced and/or metastatic cancer not amenable to standard therapy;
• any solid tumor type (Part 1); malignant melanoma, pancreatic cancer or non-small cell lung cancer (Part 2);
• measurable and/or evaluable disease (Part 1), >=1 measurable lesion (Part 2);
• ECOG performance status 0-1.

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Exclusion Criteria

• prior chemotherapy, radiotherapy or immunotherapy within 28 days of first receipt of study drug;
• prior corticosteroids as anti-cancer therapy within 14 days of first receipt of study drug;
• known past or present CNS metastases;
• acute or chronic infection.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
1	RO5126766	-

Primary Outcome Measures

Name	Time	Method
Tumor assessments (Part 2)	Event driven
Maximum tolerated dose (Part 1)	Throughout study

Secondary Outcome Measures

Name	Time	Method
AEs and laboratory parameters, ophthalmological examination, pharmacokinetic parameters, pharmacodynamic parameters (Parts 1 and 2).	Throughout study