INFLUENCE OF ACETAZOLAMIDE AND CO2 INHALATION ON PERIODIC BREATHING DURING EXERCISE IN CHRONIC HEART FAILURE - ND
- Conditions
- chronic heart failureMedDRA version: 6.1Level: PTClassification code 10007558
- Registration Number
- EUCTR2007-003836-53-IT
- Lead Sponsor
- FONDAZIONE MONZINO CENTRO CARDIOLOGICO
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Male or female in-patients, age 18-80 years,with chronic heart failure, in stable clinical conditions, with periodic breath induced by exercise documented during a cardiopulmonary exercise test.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Pregnancy, lactation, important concomitant diseases
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: to evaluate the role of CO2 and of the chemoreceptors in the genesis of periodic breath through CO2 inhalation and acute or chronic administration of acetazolamide.;Secondary Objective: na;Primary end point(s): effect on periodic breath during exercise after inhalation of C02 variation of the number of cycles of periodic breathing during chronic treatment with acetazolamide
- Secondary Outcome Measures
Name Time Method