Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Multiple Center, Cross-sectional Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,162
- 试验地点
- 1
- 主要终点
- corelation between the bile reflux and gastric mucosa diseases
研究概览
简要总结
To explore the effects of bile reflux on gastric cancer and its precancerous lesions, so as to better prevent the occurrence and development of gastric cancer.
详细描述
This study was a multicenter cross-sectional study. Patients were consecutively enrolled and divided into gastric cancer group, gastric precancerous lesions group, and chronic gastritis group, according to histopathological results. The bile reflux detection rate and Helicobacter pylori infection status were recorded for each group.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 to 75 years old, gender is not limited;
- •patients with upper abdominal pain, abdominal distension, belching, anorexia, early satiety, hiccup, acid reflux, upper abdomen burning sensation and other upper gastrointestinal symptoms;
- •Voluntary acceptance of Hp testing;
- •Voluntary acceptance of the endoscopy and pathological biopsy.
排除标准
- •had undergone upper gastrointestinal surgery;
- •Previous diagnosis of esophageal cancer;
- •Previous diagnosis of gastric cancer;
- •Previous diagnosis of MALT lymphoma;
- •pregnant and lactating women;
- •Those with mental disorders;
- •Refusal to sign the informed consent form.
结局指标
主要结局
corelation between the bile reflux and gastric mucosa diseases
时间窗: up to 6 months
we evaluate the corelation between the bile reflux and gastric mucosa diseases according to the histopathological results and the scales the patients finished
次要结局
- the risk factors of primary bile reflux gastritis(up to 6 months)
研究者
Yongquan Shi
Principal Investigator, Clinical Professor
Xijing Hospital of Digestive Diseases