NCT06031779已完成不适用
Application of Serum Bile Acid Profile in the Diagnosis of Gastric Cancer
Xijing Hospital of Digestive Diseases1 个研究点 分布在 1 个国家目标入组 1,000 人开始时间: 2023年5月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- serum bile acid profile before treatment
研究概览
简要总结
In this study, the composition and level of serum bile acids in patients with gastric cancer and non-gastric cancer were analyzed by detecting the serum bile acid profile, so as to develop new serological diagnostic methods for early diagnosis and treatment of gastric cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 18-70, both gender;
- •The gastric cancer group was early gastric cancer or advanced gastric cancer diagnosed by endoscopic examination and pathological biopsy. The non-gastric cancer group included patients without gastric lesions, superficial gastritis, chronic atrophic gastritis, intestinal metaplasia or dysplasia diagnosed by gastroscopy or pathological biopsy;
- •Informed consent was obtained.
排除标准
- •The patients have diseases that affect bile acid metabolism, such as liver cirrhosis, gallstones or inflammatory bowel disease, Behcet's disease, etc;
- •Due to other diseases, the patient took drugs affecting bile acid metabolism, such as cholestyramine, anti-inflammatory Lidan tablets, Danshu capsules, ursodeoxycholic acid, obticholic acid, Schisandrin B, tanshinone ⅡA, Yinzhihuang, etc;
- •Pregnant women;
- •Primary tumors of other systems were diagnosed;
- •Those with poor physiopathological conditions, such as chronic kidney disease requiring long-term dialysis;
- •Patients with mental illness;
- •Patients who have received radiotherapy or surgery previously;
- •Those with poor adherence or difficult to follow up.
结局指标
主要结局
serum bile acid profile before treatment
时间窗: 1 month
次要结局
- concentration of serum tumor markers before treatment(1 month)
研究者
Yongquan Shi
Principal Investigator,Clinical Professor
Xijing Hospital of Digestive Diseases
研究点 (1)
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