Comparison investigation of the effect of Letrozole misoprostol to induce abortion in the second trimester of pregnancy
Phase 2
- Conditions
- Termination of pregnancy in the second trimester.Medical abortion
- Registration Number
- IRCT2015123114333N48
- Lead Sponsor
- Vice chancellor for research, Kermanshah University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 120
Inclusion Criteria
Gestational age of 13 to 22 with an indication for termination of pregnancy in medical method; Chorioamionitic.
Exclusion criteria: Patients with a history of caesarean section; Maternal serious chronic systemic and chronic disease; Cardiovascular disease.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Duration of induction to abortion. Timepoint: From admission until 48 hours later. Method of measurement: Doctor observation.;Blood pressure. Timepoint: Baseline, every 2 hours, discharge time. Method of measurement: Manometer.;Heart rate. Timepoint: Baseline, every 2 hours, discharge time. Method of measurement: By doctor.;Temperature. Timepoint: Baseline, every 2 hours, discharge time. Method of measurement: By thermometer.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms explain letrozole's enhancement of misoprostol efficacy in second-trimester abortion?
How does the letrozole-misoprostol combination compare to standard prostaglandin protocols for second-trimester termination?
Which biomarkers correlate with successful cervical ripening in IRCT2015123114333N48 letrozole-misoprostol trials?
What adverse events are associated with aromatase inhibitor (letrozole) augmentation of misoprostol in pregnancy termination?
Are there alternative aromatase inhibitor-prostaglandin combinations for second-trimester medical abortion beyond letrozole?