the effect of misoprostol in successful Induction of medical abortio

Phase 2

Recruiting

Conditions: medical Abortion.
Missed abortion
O02.1

Registration Number: IRCT20200702047985N1

Lead Sponsor: Gorgan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 120

Inclusion Criteria

Pregnant women candidates for termination of pregnancy under 18 weeks of gestation
Missed abortions
Legal and medical abortions
Single pregnancy
Hemoglobin level> 10 g/ l
There should be no history or evidence of adrenal pathology, malignancies, porphyria, thromboembolism, severe or recurrent liver disease, or gestational pruritus
Being consent to participate in the study

Exclusion Criteria

Any sensitivity to misoprostol and letrozole
Having an intrauterine device
Having a history of more than 2 cesarean sections
Any abnormalities in pre-treatment blood tests, including CBC, liver and abnormalities in kidney function tests, including blood urea, creatinine, albumin, globulin, liver enzymes, and electrolytes
Specific medical conditions such as severe anemia, coagulation disorders, active liver disease, cardiovascular disease, glaucoma, and uncontrolled seizure disorders
Having a history of thromboembolism, adrenal diseases, steroid-dependent cancer, porphyria, and disorders that require treatment with glucocorticoids, such as bronchial asthma

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Percentage of induction of successful fetal abortion with transvaginal ultrasound. Timepoint: group A members will receive up to 10 mg letrozole (2.5 mg letrax tablets, made by Abu Reihan Pharmaceuticals [Iran]) on days 1 to 3. Group B members will also receive placebo tablets, similar in appearance and taste to letrozole tablets , on days 1 to 3 .finally all patients will undergo transvaginal ultrasound on the fifth day after medical therapy. Method of measurement: Transvaginal ultrasound for successful abortion and BHCG check.

Secondary Outcome Measures

Name	Time	Method
Side Effects of Misoprostol. Timepoint: During the study, blood pressure, heart rate and patient temperature will be checked every four hours by the ward nurse and side effects including fever (body temperature more than 38 degrees of Celsius), sweating, hot flashes, arthralgia and fatigue, nausea, vomiting, bone pain, dizziness, muscle aches, diarrhea, abdominal pain, stomach pain, vaginal bleeding, sore throat, pain when urinating, difficulty in urinating, cough, rash, flu-like symptoms, difficulty in sleeping or in staying asleep, amount of bleeding, and the time of discarding of the residual tissue will be recorded by the resident and these data will be written in the patient's dossier. Method of measurement: Measuring fever with a thermometer and measuring blood pressure with a cuff pressure gauge, clinical examinations and a history of the patient.