To compare and evaluate the effect of mild versus moderate haemodilution during cardiopulmonary bypass on the neurological complications in patients undergoing heart valve replacement surgery.
Phase 3
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/09/057179
- Lead Sponsor
- Department of Anaesthesiology, SMS Medical College and Attached Hospitals.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Informed written consent.
Patients with valvular surgery.
Aged between 30 and 60 years.
Exclusion Criteria
Previous neurological disease.
Congestive heart failure.
Diabetes, Hypertension.
Acute Myocardial Infarction.
Atrial fibrillation or obstructive cardiomyopathy.
Renal or Hepatic Impairment.
HCT < 21%
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method eurological Complications <br/ ><br>Cerebral oximetry values.Timepoint: On post op day 2,4, 6. <br/ ><br>During Surgery 15 & 30 minutes after initiation of Cardiopulmonary bypass and 5 minutes before weaning of cardiopulmonary bypass.
- Secondary Outcome Measures
Name Time Method Hemodynamic Variables PR, MAP, CVP, SpO2.Timepoint: Baseline, 15 minutes after intubation, before cardiopulmonary bypass, 30 minutes after cardiopulmonary bypass, at ICU admission, 6hours, 12hours & 24 hours after ICU admission.