Efficacy of autologous platelet-rich fibrin (PRF) over moist sterile saline dressing in chronic trophic ulcers in Hansenâ??s disease patients â?? a Randomised Control Trial.

JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH0 sites66 target enrollmentTBD

ConditionsHealth Condition 1: null- LEPROSY WITH TROPHIC ULCERS

Overview

Phase: 未知
Intervention: Not specified
Conditions: Health Condition 1: null- LEPROSY WITH TROPHIC ULCERS
Sponsor: JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH
Enrollment: 66
Status: Recruiting
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

No summary available.

Registry

who.int

Start Date

TBD

End Date

TBD

Last Updated

4 years ago

Study Type

Interventional

Investigators

Sponsor

JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH

Eligibility Criteria

Inclusion Criteria

•Patients with Hansenâ??s disease who have chronic trophic ulcers of lower extremity of \> 6 months duration, attending the dermatology out\-patient department in JIPMER, having an ulcer area of 1cm x 1cm to 5cm x 5 cm, and belonging to stage II or stage III of the European Pressure Ulcer Advisory Panel (EPUAP) scheme

Exclusion Criteria

•Ulcers \< 6 months duration.
•Ulcers of other etiology e.g. venous ulcer/arterial ulcer/diabetic ulcer/ulcer with underlying vasculitis.
•Patients with osteomyelitis affecting the area of the ulcer.
•Ulcers with exposure of tendons or bones.
•Ulcers with area \<1cm x 1cm or \> 5cm x 5cm
•Ulcers with copious discharge /overt infection /infected with Pseudomonas.
•Patients with HIV/ HBsAg/ HCV
•Hemoglobin \< 11 gm/dl and/or platelet count \< 1,50,000/ mm3
•Serum albumin \< 4\.5 mg/dl
•Patients with malignancy/ uncontrolled diabetes mellitus/received radiation therapy/on drugs like steroids, immunosuppressive agents/compromised cardiopulmonary status/ compromised endocrine status/ acid\-base imbalance/ renal failure/ liver failure/ any other factor impairing wound healing.

Outcomes

Primary Outcomes

Not specified

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