Effects of the Use of Platelet-rich Fibrin on Bone Regeneration After Impacted Third Molar Surgery

Not Applicable

Completed

• Conditions: Fibrin/Therapeutic Use; Blood Platelets; Molar, Third; Bone Regeneration
• Interventions: Procedure: Platelet-rich fibrin; Procedure: Control group

• Registration Number: NCT02890680
• Lead Sponsor: Rio de Janeiro State University

Brief Summary

The purpose of this study is to evaluate the bone regeneration after impacted third molar surgery on split mouth design using platelet-rich fibrin.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-08
• Study First Submitted: 2016-08-24
• Study First Submitted QC: 2016-08-31
• Study First Posted: 2016-09-07
• Primary Completion: 2016-11
• Study Completion: 2017-01
• Status Verified: 2017-04
• Last Update Submitted: 2017-04-10
• Last Update Posted: 2017-04-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Healthy patients
• Preoperative platelet count higher than 150,00/ mm3
• Patient who required bilateral mandibular third molar extractions

Exclusion Criteria

• Smokers patients
• Alcoholics patients
• Patients whom the inferior second molar was missing
• Patients who had acute pericoronitis on the inferior third molar
• Severe periodontal disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Platelet-rich fibrin group	Platelet-rich fibrin	Use platelet-rich fibrin after mandibular third molar extraction
Control group	Control group	mandibular third molar extraction

Primary Outcome Measures

Name	Time	Method
Change in bone density through tomography evaluation	Change from Baseline bone measurement at three months after surgery

Secondary Outcome Measures

Name	Time	Method
Change in periodontal-probing depth measurement on distal aspect of the second molar through Clinical evaluation	Change from baseline at 3 months after surgery
Pain through Visual Analogue Scale	7th day after surgery
Soft tissue healing through Clinical evaluation numeric scale	7th day after surgery

Trial Locations

Locations (1)

João Canellas; 🇧🇷 Rio de Janeiro, Brazil