The effect of Coriander seed on gastro-esophageal reflux disease

Early Phase 1

Conditions: Gastroesophageal reflux.
Gastro-esophageal reflux disease

Registration Number: IRCT20230611058455N1

Lead Sponsor: Ghoum University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 110

Inclusion Criteria

Age 18 to 60
Outpatients with history of at least 4 weeks of major reflux symptoms in the last 3 months
Informed consent to participating in the study
Consent to avoiding out of protocol medication

Exclusion Criteria

History of gastrointestinal cancers in the patient and first degree relatives
History of esophageal, abdominal or stomach surgery
Suffering from diabetes, acute peptic ulcer, achalasia and acute gastrointestinal diseases, gastrointestinal bleeding, iron deficiency anemia, anorexia, persistent vomiting, unexplained weight loss, pregnancy
Taking aspirin and warfarin/taking herbal medicines one month before the study
Impotency and sperm production disorders/severe amnesia
Presence of dysphagia and odynophagia
History of obstructive diseases(kidney and gallbladder stone)\amenorrhea or oligomenorrhea

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Symptoms of gastro-esophageal reflux disease. Timepoint: At the beginning of the stydy, the end of the third week and the end of the sixth week. Method of measurement: Frequency Scale for the Symptoms of GERD (FSSG)Questionnaire.

Secondary Outcome Measures

Name	Time	Method
Evaluation of quality of life in reflux and dyspepsia. Timepoint: At the beginning of the study,the end of the third week and the end of the sixth week. Method of measurement: Quality of Life in Reflux and Dyspepsia(QOLRAD)Questionnaire.