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Clinical Trials/NCT02858115
NCT02858115CompletedNot Applicable

Use of Mini-fluid Challenge for Fluid Responsiveness Prediction During One-lung Ventilation

Assistance Publique Hopitaux De Marseille1 site in 1 country50 target enrollmentStarted: January 2014Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
50
Locations
1
Primary Endpoint
Velocity time index

Study Overview

Brief Summary

During thoracic surgery, an excessive use of fluid results in pulmonary complications. Dynamic fluid responsiveness predictors are not easily usable during one lung ventilation. The investigators hypothesized that the assessment by transesophageal echocardiography (TEE) of subaortic velocity time index (VTI) variation after 100 ml of crystalloid would predict fluid responsiveness in patients receiving one-lung ventilation.

This retrospective, observational, single center study was from January 2014 to December 2015. The investigators included 105 patients requiring one lung ventilation lung resection. The investigators analysed 39 patients presenting an acute circulatory failure. 100 ml of crystalloid was infused over 1-min. After an echocardiographic assessment at 1-min, remaining 400 ml were administered over 14-min Fluid responsiveness was defined as an increase in the VTI above 15% after infusion of 500 ml of crystalloid.

Study Design

Study Type
Observational
Time Perspective
Retrospective

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Lung resection
  • Acute circulatory failure
  • One-lung ventilation

Exclusion Criteria

  • Sinusal rhythm

Outcomes

Primary Outcomes

Velocity time index

Time Frame: one day

: Echographic assesment of cardiac output

Fluid responsiveness

Time Frame: one day

increase of cardiac output of more than 15%

Secondary Outcomes

  • Pulsed pressure variation(one day)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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