The Effectiveness of Mini-fluid Challenge in Predicting Fluid Responsiveness During Video Assisted Thoracic Surgery

Not Applicable

• Conditions: Mini-fluid Challenge in Video-Assisted Thoracic Surgery
• Interventions: Drug: Crystalloid Solutions

• Registration Number: NCT03731377
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Perioperative fluid management is crucial for patients' outcome. Muller et al developed a "Mini-fluid challenge method " to predict fluid responsiveness and the efficacy. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in video assisted thoracic surgery.

Detailed Description

Perioperative fluid management is crucial for patients' outcome. Series of studies have indicated that adequate fluid management optimizes the cardiac out put, improves tissue perfusion, thus decrease the risk of postoperative morbidity. Muller et al developed a "Mini-fluid challenge method " to predict fluid responsiveness and the efficacy. Fluid status and proper perfusion condition in patients undergo thoracic surgery are especially crucial for the vulnerability of lung toward fluid overload. To the best of our knowledge, the efficacy of the test was not discussed in the perioperative care in video assisted thoracic surgery. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in video assisted thoracic surgery.

Study Timeline

• Study First Submitted: 2018-10-01
• Study First Submitted QC: 2018-11-04
• Study First Posted: 2018-11-06
• Status Verified: 2020-10
• Last Update Submitted: 2020-10-05
• Study Start: 2020-10-07
• Last Update Posted: 2020-10-08
• Primary Completion: 2021-11
• Study Completion: 2021-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients receiving scheduled video assisted thoracic surgery
• BMI 18.5~30 kg.m-2

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Exclusion Criteria

• age younger then 20 yrs or elder than 80 yrs
• pregnant women
• patients in intensive care units
• patients with the underlying disease including respiratory failure(FEV1/FVC < 70 % and FEV1 < 50%), heart failure(NYHA score =III、IV), kidney failure(eGFR< 60 ml.min-1.1.73m-2), liver failure
• patients with ongoing infection
• patient allergic to voluven

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Intubated group	Crystalloid Solutions	Patient in this group will receive general anesthesia with endotracheal tube intubation to perform one lung ventilation. Patient will be paralyzed and controlled ventilation will be implied.
Non-intubated group	Crystalloid Solutions	Patient in this group will receive general anesthesia with laryngeal mask insertion. Patients in this group will not be paralyzed and keep spontaneous breathing to maintain one lung ventilation.

Primary Outcome Measures

Name	Time	Method
Change of blood pressure after fluid loading	3 hours	Interpretate the correlation of mini-fluid challenge and conventional fluid challenge

Secondary Outcome Measures

Name	Time	Method
Change of cardiac index after fluid loading	3 hours	Interpretate the correlation of mini-fluid challenge and conventional fluid challenge

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan