The Effectiveness of Mini-fluid Challenge in Predicting Fluid Responsiveness During Video Assisted Thoracic Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Crystalloid Solutions
- Conditions
- Mini-fluid Challenge in Video-Assisted Thoracic Surgery
- Sponsor
- National Taiwan University Hospital
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Change of blood pressure after fluid loading
- Last Updated
- 5 years ago
Overview
Brief Summary
Perioperative fluid management is crucial for patients' outcome. Muller et al developed a "Mini-fluid challenge method " to predict fluid responsiveness and the efficacy. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in video assisted thoracic surgery.
Detailed Description
Perioperative fluid management is crucial for patients' outcome. Series of studies have indicated that adequate fluid management optimizes the cardiac out put, improves tissue perfusion, thus decrease the risk of postoperative morbidity. Muller et al developed a "Mini-fluid challenge method " to predict fluid responsiveness and the efficacy. Fluid status and proper perfusion condition in patients undergo thoracic surgery are especially crucial for the vulnerability of lung toward fluid overload. To the best of our knowledge, the efficacy of the test was not discussed in the perioperative care in video assisted thoracic surgery. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in video assisted thoracic surgery.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients receiving scheduled video assisted thoracic surgery
- •BMI 18.5\~30 kg.m-2
Exclusion Criteria
- •age younger then 20 yrs or elder than 80 yrs
- •pregnant women
- •patients in intensive care units
- •patients with the underlying disease including respiratory failure(FEV1/FVC \< 70 % and FEV1 \< 50%), heart failure(NYHA score =III、IV), kidney failure(eGFR\< 60 ml.min-1.1.73m-2), liver failure
- •patients with ongoing infection
- •patient allergic to voluven
Arms & Interventions
Intubated group
Patient in this group will receive general anesthesia with endotracheal tube intubation to perform one lung ventilation. Patient will be paralyzed and controlled ventilation will be implied.
Intervention: Crystalloid Solutions
Non-intubated group
Patient in this group will receive general anesthesia with laryngeal mask insertion. Patients in this group will not be paralyzed and keep spontaneous breathing to maintain one lung ventilation.
Intervention: Crystalloid Solutions
Outcomes
Primary Outcomes
Change of blood pressure after fluid loading
Time Frame: 3 hours
Interpretate the correlation of mini-fluid challenge and conventional fluid challenge
Secondary Outcomes
- Change of cardiac index after fluid loading(3 hours)