Mini-fluid Challenge in Predicting Fluid Responsiveness During Prone Position Spine Surgery

Not Applicable

Completed

• Conditions: Anesthesia
• Interventions: Other: Mini-fluid challenge

• Registration Number: NCT03089710
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Perioperative fluid management is crucial for patients' outcome. Muller et al developed a "Mini-fluid challenge method " to predict fluid responsiveness and the efficacy. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in prone position surgery.

Detailed Description

Perioperative fluid management is crucial for patients' outcome. Series of studies have indicated that adequate fluid management optimizes the cardiac out put, improves tissue perfusion, thus decrease the risk of postoperative morbidity. Muller et al developed a "Mini-fluid challenge method " to predict fluid responsiveness and the efficacy. To the best of our knowledge, the efficacy of the test was not discussed in the perioperative care in prone position surgery. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in prone position surgery.

Study Timeline

• Study First Submitted: 2017-02-22
• Study First Submitted QC: 2017-03-20
• Study First Posted: 2017-03-24
• Study Start: 2017-03-31
• Primary Completion: 2018-09-14
• Study Completion: 2018-09-14
• Status Verified: 2018-10
• Last Update Submitted: 2020-02-09
• Last Update Posted: 2020-02-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

meet both of

1. Patients receiving scheduled prone position spine surgery
2. BMI 18.5~30 kg.m-2

Exclusion Criteria

1. age younger then 20 yrs or elder than 80 yrs
2. pregnant women
3. patients in intensive care units
4. patients with the underlying disease including respiratory failure(FEV1/FVC < 70 % and FEV1 < 50%), heart failure(NYHA score =III、IV), kidney failure(eGFR< 60 ml.min-1.1.73m-2), liver failure
5. patients with ongoing infection
6. patients allergic to voluven

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Mini-Fluid Challenge arm	Mini-fluid challenge	Fluid challenge test will be presented after induction of anesthesia at a steady state. Fluid challenge test includes 2 components: 100 ml colloid infusion in 1 min followed by 400 ml colloid infusion in 14 mins. Hemodynamic parameter after 1 minute of the end of the 1st and 2nd colloid infusion bolus will be collected. Applied colloid: hydroxyethyl starch

Primary Outcome Measures

Name	Time	Method
Change of cardiac index after fluid loading	3hr	interpretate the correlation of mini-fluid challenge and conventional fluid challenge

Secondary Outcome Measures

Name	Time	Method
pulse pressure variation(PPV)	3hr	interpretate the correlation of PPV and conventional fluid challenge

Trial Locations

Locations (1)

National Taiwan University; 🇨🇳 Taipei, Taiwan