Changing or Substituting Low-calorie Sweetened Beverages for Sugar-Sweetened Beverages or Water and Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Prospective Cohort Studies
试验速览
- 阶段
- 不适用
- 入组人数
- 1
- 试验地点
- 1
- 主要终点
- Global measures of adiposity with established clinical relevance - body weight
研究概览
简要总结
We propose to conduct a systematic literature review and meta-analysis to assess the association of low-calorie sweetened beverages (LCSBs) on cardiometabolic outcomes in prospective cohort studies. We will be using methodological approaches (change in LCSBs intake, and/or substitution analysis) that attempt to overcome the issue of reverse causality associated with studies of LCSBs and cardiometabolic disease. Ten cardiometabolic outcomes will be assessed:
- Global adiposity - body weight
- Global adiposity - BMI
- Global adiposity - body fat
- Abdominal adiposity - waist circumference
- Overweight/obesity incidence
- Metabolic syndrome incidence
- Type 2 diabetes incidence
- Cardiovascular disease incidence
- Cardiovascular disease mortality
- Total mortality
详细描述
Background:
Low-calorie sweetened beverages (LCSBs) may provide a potentially important means for displacing excess calories from free sugars in the diet. However, prospective cohort studies suggest that the use of LCSBs may contribute to an increased risk of obesity and diabetes. These findings are likely due to methodological limitations of study design and analysis that do not account for reverse causality, where higher risk of cardiometabolic outcomes may lead to people to switch to LCSBs. There is a need for a systematic review and meta-analysis (SRMA) of prospective cohort studies to overcome these methodological limitations.
Objective:
We will conduct a SRMA of prospective cohort studies in human subjects that have assessed cardiometabolic outcomes using two analytical strategies:
i) Assessment of change in intake of LCSBs with change in outcome (change analysis)
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Prospective cohorts studies
- •Duration: more than 1 year follow-up
- •Exposure: LCSBs
- •Change analysis or substitution analysis of exposure
排除标准
- •Non-human studies
- •Less than 1 year follow-up
- •Analysis of baseline or prevalent intake of exposure only
结局指标
主要结局
Global measures of adiposity with established clinical relevance - body weight
时间窗: More than 1 year
Change in body weight
Global measures of adiposity with established clinical relevance - BMI
时间窗: More than 1 year
Change in body mass index (BMI)
Global measures of adiposity with established clinical relevance - body fat
时间窗: More than 1 year
Change in body fat
Abdominal measures of adiposity with established clinical relevance - waist circumference
时间窗: More than 1 year
Change in waist circumference
Overweight/obesity incidence
时间窗: More than 1 year
Risk ratio of Overweight/obesity incidence
Metabolic syndrome incidence
时间窗: More than 1 year
Risk ratio of metabolic syndrome incidence
Type 2 diabetes incidence
时间窗: More than 1 year
Risk ratio of type 2 diabetes incidence
Cardiovascular disease incidence
时间窗: More than 1 year
Risk ratio of cardiovascular disease incidence
Cardiovascular disease mortality
时间窗: More than 1 year
Risk ratio of Cardiovascular disease mortality
Total mortality
时间窗: More than 1 year
Risk ratio of total mortality
次要结局
未报告次要终点
研究者
John Sievenpiper
Associate Professor
University of Toronto