A study to compare the effect of Dexmedetomidine and Lignocaine in attenuating haemodynamic response to laryngoscopy and endotracheal intubation

Not yet recruiting

• Conditions: Measurement and Monitoring, (2) ICD-10 Condition: O||Medical and Surgical,

• Registration Number: CTRI/2021/07/034519
• Lead Sponsor: Ruth Lalnuntawmpuii

Brief Summary

This is a study to compare the efficacy of 0.75mcg/kg of IV Dexmedetomidine and 1.5mg/kg of IV Lignocaine, in attenuating haemodynamic response to laryngoscopy and endotracheal intubation, which will be conducted in the department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal, Manipur, in 64 patients, aged 18-60 years, with ASA grade I and II. The study drug will be given 5 minutes prior to induction with 2mg/kg IV Propofol. The haemodynamic parameters will be recorded till 5 minutes post intubation and will be analysed.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-01-07
• Study Start: 2021-02-07

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

ASA grade I and II and patients posted for elective surgery who has given consent.

Exclusion Criteria

• ASA grade III and IV 2.
• Uncontrolled hypertension, diabetes, cardiac, renal, hepatic, cerebral and peripheral vascular diseases 3.
• Bradycardia 4.
• Morbid obesity 5.
• History of allergy to study drugs 6.
• Patients in whom intubation attempts lasted longer than 15 seconds 7.
• Patients with anticipated difficult airway.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Haemodynamic response to laryngoscopy and endotracheal intubation	Haemodynamic response to laryngoscopy and endotracheal intubation duting intubation, 1 minute, 2 minutes, 3 minutes and 5 minutes after intubation

Trial Locations

Locations (1)

Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal; 🇮🇳 West, MANIPUR, India

Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal

🇮🇳West, MANIPUR, India

Ruth Lalnuntawmpuii

Principal investigator

9615489966

ruthralte21@gmail.com