Assessing Feasibility and Utility of Enhancing Medication Therapy Management With Pharmacist-Delivered Pharmacogenetic Testing
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Number of recommended drug selection/dosing adjustments
研究概览
简要总结
This study aims to investigate the benefit and feasibility of providing pharmacogenetic (PGx) testing as part of a standard medication therapy management (MTM) session for patients taking multiple medications, a high-risk population for adverse drug reactions and non-response. Research participants will attend two MTM sessions and undergo PGx testing to inform the MTM plan. Participants will also complete 2 surveys pre and post-MTM/PGx testing. Data analysis will assess the impact of MTM/PGx testing on recommendations for drug dosing, clinical outcomes, patient satisfaction, and feasibility of service delivery. Safety issues are minimal with the primary risks being associated with loss of confidentiality, typical discomfort associated with acquiring blood samples, and genetic discrimination.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •currently prescribed 3 medications, one of which must be simvastatin or clopidogrel
- •18 years of age or older
- •English speaking
- •patients of Mahesh Patel or William Kraus at Duke Southpoint Clinic
排除标准
- •if patient has ever had MTM or PGx
结局指标
主要结局
Number of recommended drug selection/dosing adjustments
时间窗: approximately 9 months
Drug selection/doing changes will be compared between study population and chart-review controls
Patient satisfaction with MTM and PGx
时间窗: 3 months after completion of MTM2
This will be assessed by a quantitative survey
Change in clinical biomarkers associated with drug therapy
时间窗: baseline and 2 months
Changes in biomarkers before and after MTM/PGx will be measured. Biomarkers of study group will be compared to chart-review control
次要结局
- Physician time to perform MTM and PGx(end of study, approx. 9 months)
