Preperation and characterization of lipospmal Epidermal growth factor and evaluating its efficacy on preorbital wrinkles

Phase 1

Conditions: Aging and preorbital wrinkle.

Registration Number: IRCT20141007019432N7

Lead Sponsor: Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 15

Inclusion Criteria

Aged between 35 to 50 years old.
Having a healthy face for dermatological, anatomical and sympathetic diseases
Being in the wrinkle grade 2 and 3 according to the Lemperle 4 table
Having psychological and social health (based on self-expression)
Having knowledge And have enough time to cooperate until the end of the plan

Exclusion Criteria

Without any restorative intervention in the form of sub-sission , botox, filler, lift and surgery and etc,
Having plenty of wrinkles in different areas of the skin
Mental and social obsessive-compulsive disorder (based on self-declaration)
history of related skin diseases, autoimmune, allergies or inflammation near the site
history of prematurity cardiovascular, respiratory, diabetes, wound healing, moderate to high anemia, and other diseases that affect the process of rejuvenation
history of systemic diseases
history of oral and maxillofacial infections
positive screening tests HIV1.2Ab, HBsAg, HbcAb, HCVAb,

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect of liposomal epidermal growth factor production on the surface and depth of preorbital wrinkle. Timepoint: before intervention and 3 months after using. Method of measurement: The statistical population is according to the degree of wrinkles 2 and 3 in thecase of women aged between 35 and 50 years that are selected by written consent. In this study, viscosity of the skin with visioface (D1000 ck Cologne, Germany), the level and degree of wrinkle with the set (LL 650 CK Germany), the thickness and density of the skin, the dermal and epidermal with ultrasound skin scanner, DUB-TPA EOTECH, Marcoussis, France), Multiprobe , elasticity with Adapter Cutometer (Cologne, Germany) ,skin water levels by chronometer devices are examined before and after using cream for 3 months and the numbers will be compared. All statistical analyses will be done in SPSS software.

Secondary Outcome Measures

Name	Time	Method
Effect of liposomal epidermal growth factor production on moisture ,elasticity and dermal -epidermal thickness,. Timepoint: before intervention and 3 months after using. Method of measurement: The statistical population is according to the degree of wrinkles 2 and 3 in thecase of women aged between 35 and 50 years that are selected by written consent. In this study, viscosity of the skin with visioface (D1000 ck Cologne, Germany), the level and degree of wrinkle with the set (LL 650 CK Germany), the thickness and density of the skin, the dermal and epidermal with ultrasound skin scanner, DUB-TPA EOTECH, Marcoussis, France), Multiprobe , elasticity with Adapter Cutometer (Cologne, Germany) ,skin water levels by chronometer devices are examined before and after using cream for 3 months and the numbers will be compared. All statistical analyses will be done in SPSS software.