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Blood Indices of Systemic Inflammation in Critically Ill Patients With Abdominal Sepsis

Not yet recruiting
Conditions
Abdominal Sepsis
Critically Ill
Registration Number
NCT06095830
Lead Sponsor
Assiut University
Brief Summary

This study aims to clarify the role of blood indices of systemic inflammation in ICU-admitted patients with abdominal sepsis to assess their diagnostic significance as well as their prognostic value.

Detailed Description

Sepsis is a complex, multifactorial syndrome which can evolve into conditions of varying severity. If left untreated, it may lead to the functional impairment of one or more vital organs or systems. Severity of illness and the inherent mortality risk escalate from sepsis, through severe sepsis (defined as sepsis associated with at least one acute organ dysfunction, hypoperfusion, or hypotension) and septic shock up multi-organ failure. Previous studies have demonstrated that mortality rates increase dramatically in the event of severe sepsis and septic shock.

Abdominal infection is a common indication for admission to the intensive care unit (ICU) and the abdomen is the second most common site of invasive infection among critically ill patients in epidemiological and therapeutic studies. Abdominal infections are more often associated with septic shock and acute kidney injury than are infections in other sites. The spectrum of disease and severity is broad and management of these infections is challenging.

The inflammatory response in patients with sepsis depends on the causative pathogen and the host (genetic characteristics and coexisting illnesses), with differential responses at local, regional, and systemic levels.

On the systemic level, several indices have been used as a mirror to outcome in patients with various pathologies, of which are the Blood Indices of Systemic Inflammation.

As these blood indices are easy and available investigation that may be promising predictors in sepsis, we aim in this study to evaluate their role in abdominal sepsis.

Recruitment & Eligibility

Status
NOT_YET_RECRUITING
Sex
All
Target Recruitment
120
Inclusion Criteria
  1. Patients above the age of 18 years old.
  2. Patients fulfilling the Systemic Inflammatory Response Syndrome (SIRS) criteria.
  3. Patients with an established diagnosis of abdominal sepsis, clinically and by investigations.
Exclusion Criteria
  1. Patients below the age of 18 years.
  2. Patients with haematological disorders.
  3. Patients with concomitant severe morbidity affecting the prognosis other than sepsis e.g. hypovolemic shock, brainstem infarction, pulmonary embolism, etc.

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Estimation of the prognostic value of blood indices of systemic inflammationBaseline

Correlate between the blood indices of systemic inflammation and the prognosis of the patients.

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Assiut University Hospitals

🇪🇬

Assiut, Egypt

Assiut University Hospitals
🇪🇬Assiut, Egypt
Safaa Abdelsattar, Prof
Contact
+201064170058
Safaakhaled2003@gmail.com
Dina Hammad, Prof
Contact
+201063040703
Dinaalihamad@aun.edu.eg

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