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Clinical Trials/ISRCTN12417565
ISRCTN12417565
Completed
未知

REviewing long term anti-DEpressant Use by Careful monitoring in Everyday practice (REDUCE) programme. Workstream 5 (WS5): Randomised Controlled Trial

niversity of Southampton0 sites330 target enrollmentOctober 7, 2019
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ConditionsMood [affective] disordersMental and Behavioural Disorders

Overview

Phase
未知
Intervention
Not specified
Conditions
Mood [affective] disorders
Sponsor
niversity of Southampton
Enrollment
330
Status
Completed
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

2020 Protocol article in https://pubmed.ncbi.nlm.nih.gov/32448374/ protocol (added 26/05/2020) 2024 Results article in https://pubmed.ncbi.nlm.nih.gov/38913372/ (added 25/06/2024)

Registry
who.int
Start Date
October 7, 2019
End Date
March 30, 2023
Last Updated
last year
Study Type
Interventional
Sex
All

Investigators

Sponsor
niversity of Southampton

Eligibility Criteria

Inclusion Criteria

  • •1\. Patients who are taking long\-term antidepressant treatment, which is not indicated according to the NICE depression guideline (NICE, 2009\):
  • •1\.1 Treated for more than 1 year for a first episode, and
  • •1\.2 Treated for more than 2 years for a recurrent episode, who are:
  • •1\.3 No longer depressed or judged to be at significant risk of relapse
  • •2\. Adults over 18 years

Exclusion Criteria

  • •1\. At risk for relapse:
  • •1\.1 Current significant depressive symptoms on the PHQ\-9 (see below) despite antidepressant treatment
  • •1\.2 Current significant anxiety symptoms on the GAD\-7
  • •1\.3 Current suicidal ideas
  • •1\.4 Current psychiatric outpatient or inpatient treatment for depression
  • •2\. Bipolar disorder, comorbid psychosis, substance use, or dementia as a primary diagnosis
  • •3\. Spoken or written English language inadequate to take part in interviews or complete questionnaires
  • •4\. Another indication for taking antidepressants, e.g. neuropathic pain

Outcomes

Primary Outcomes

Not specified

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