REviewing long term anti-DEpressant Use by Careful monitoring in Everyday practice (REDUCE) programme. Workstream 5 (WS5): Randomised Controlled Trial

niversity of Southampton0 个研究点目标入组 330 人开始时间: 2019年10月7日最近更新: 2024年7月8日

适应症

试验速览

2020 Protocol article in https://pubmed.ncbi.nlm.nih.gov/32448374/ protocol (added 26/05/2020) 2024 Results article in https://pubmed.ncbi.nlm.nih.gov/38913372/ (added 25/06/2024)

•1. Patients who are taking long-term antidepressant treatment, which is not indicated according to the NICE depression guideline (NICE, 2009):
•1.1 Treated for more than 1 year for a first episode, and
•1.2 Treated for more than 2 years for a recurrent episode, who are:
•1.3 No longer depressed or judged to be at significant risk of relapse
•2. Adults over 18 years

•1. At risk for relapse:
•1.1 Current significant depressive symptoms on the PHQ-9 (see below) despite antidepressant treatment
•1.2 Current significant anxiety symptoms on the GAD-7
•1.3 Current suicidal ideas
•1.4 Current psychiatric outpatient or inpatient treatment for depression
•2. Bipolar disorder, comorbid psychosis, substance use, or dementia as a primary diagnosis
•3. Spoken or written English language inadequate to take part in interviews or complete questionnaires
•4. Another indication for taking antidepressants, e.g. neuropathic pain

发起方

niversity of Southampton