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临床试验/CTRI/2021/03/032024
CTRI/2021/03/032024尚未招募不适用

Effect of High flow nasal cannula versus conventional Venturi mask oxygenation after planned extubation in intensive care unit patients.

Maulana Azad medical college1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2021年3月25日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
40
试验地点
1
主要终点
The number of patients requiring non invasive ventilation or reintubation after planned extubation

研究概览

简要总结

Majority of  ICU patients often require endotracheal intubation and mechanical ventilation .As a standard protocol, intubated ICU patients after the resolution of underlying disease are gradually weaned from mechanical ventilation and there after extubated. Oxygenation and ventilation impairment may be seen in some patients after extubation. Post extubation respiratory management by supplemental oxygen therapy aims at decreasing early post extubation respiratory failure. Several devices are available for delivering oxygen to the ICU patients, which can be either a high flow system or low flow system . Venturi mask being routinely used since years for oxygen supplementation after extubation. It is a high flow oxygen delivery device which has the advantage of delivering precise Fio2 upto a maximum of 0.60.Inspite of being a high flow device it has disadvantage of air entrainement when the respiratory demand of patient increases leading to dilution of oxygen and also delivers non humidified oxygen which leads to airway mucosa dryness.

Recently a new high flow device (AIRVO2) is being increasingly used. In this high flow device patients inhale a higher percentage of oxygen which saturates the nasopharynx with oxygen and increases the oxygen reserve in lungs. It can deliver oxygen upto 70L/min and FiO2 reaching upto 0.99-1.00.Gaseous exchange is facilitated by flow dependant dead space flushing .

We hypothesize that High Flow Nasal Cannula (AIRVO2) may provide better oxygenation and comfort to the patient with better recruitement of alveoli after planned extubation than conventional oxygen therapy.

研究设计

研究类型
Interventional
分配方式
Computer generated randomization
盲法
Not Applicable

入排标准

年龄范围
18.00 Year(s) 至 65.00 Year(s)(—)
性别
All

入选标准

  • •1.BMI < 30 2.≤1 co morbidities 3.Minimum 12 hours and maximum of 7 days of intubaton period.

排除标准

  • •1.Patients with congestive heart disease 2.Patients with moderate to severe COPD 3.Pregnant Patients 4.Patients who are planned for non invasive ventilation after intubation.

结局指标

主要结局

The number of patients requiring non invasive ventilation or reintubation after planned extubation

时间窗: From the time of extubation till 24 hours after extubation.

次要结局

  • 1.Time to non invasive ventilation/reintubation(2.Pao2/FiO2 ratio and PaCO2)

研究者

申办方类型
Government medical college

研究点 (1)

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