Application of Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Asymptomatic Lung Transplant Recipients
Overview
- Phase
- Not Applicable
- Intervention
- Lung ultrasound
- Conditions
- Post-Lung Transplantation Bronchiectasis
- Sponsor
- Mayo Clinic
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- Establish predictive value of lung ultrasound
- Status
- Recruiting
- Last Updated
- 2 months ago
Overview
Brief Summary
This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.
Detailed Description
Lung transplant recipients are at high risk for lung rejection and lung infection after transplant. This is diagnosed by performing lung bronchoscopies and lung biopsies. These procedures carry an increased risk for complications and are costly. This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.
Investigators
Tathagat Narula
Principal Investigator
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- •Adult patients (\> 18 yrs) who had undergone single/double/heart-lung transplant
- •Asymptomatic
- •Normal spirometry defined as a FEV1 without significant drop from baseline (significant drop = \>10% decrease from baseline)
- •Clear chest radiograph over allograft
Exclusion Criteria
- •Patients who are unable to consent for the procedure
- •Patients with subcutaneous emphysema or other technical challenges that could interfere with satisfactory image acquisition- as deemed by the operator.
Arms & Interventions
Receiving Ultrasound
Every patient will receive a lung ultrasound prior to each scheduled bronchoscopy until the study stops.
Intervention: Lung ultrasound
Outcomes
Primary Outcomes
Establish predictive value of lung ultrasound
Time Frame: Month 0 to month 12
Determine if lung ultrasound provides the same diagnostic results as bronchoscopy and biopsy