Effect-site Concentration of Propofol for I-gel Insertion During Anesthesia Induction With a Single-dose Dexmedetomidine

Not Applicable

Completed

• Conditions: Igel
• Interventions: Drug: propofol concentration

• Registration Number: NCT02268656
• Lead Sponsor: Gachon University Gil Medical Center

Brief Summary

Before anethetic induction, infuse dexmedetomidine 0.5 mcg/kg for 2 minutes and after injection of lidocaine 30 mg, propofol infusion by using target controlled infusion (TCI) pump. Effect site concentraion of propofol start from 5 and changes the concentration as previous response to i-gel insertion as up and down methods

Detailed Description

Before anethetic induction, infuse dexmedetomidine 0.5 mcg/kg for 2 minutes and after injection of lidocaine 30 mg, propofol infusion by using target controlled infusion (TCI) pump. Effect site concentraion of propofol start from 5 and changes the concentration as previous response to i-gel insertion as up and down methods. Failure of previous subjects are defined as difficulty to mouth open, severe nausea and couph and laryngeal spasm, and not loss of consciousness.

Study Timeline

• Study Start: 2014-10
• Study First Submitted: 2014-10-09
• Study First Submitted QC: 2014-10-16
• Study First Posted: 2014-10-20
• Primary Completion: 2015-02
• Study Completion: 2015-02
• Results First Submitted: 2019-02-14
• Status Verified: 2022-08
• Results First Submitted QC: 2022-08-01
• Last Update Submitted: 2022-08-01
• Results First Posted: 2022-08-03
• Last Update Posted: 2022-08-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• ASA PS I-II, 20-60 yrs old

Exclusion Criteria

• predicted difficulty airway, recent URI, BMI > 30kg/m2, reactive airway disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
concentration of propofol in male	propofol concentration	after infusion of dexmedetomidine dexmedetomidine 0.5 mcg/kgfor 2 min, infusion of propofol as using target controlled infusion pump. Effect site concentration would be changed as the response to i-gel insertion as up and down method in male
concentration of propofol in female	propofol concentration	after infusion of dexmedetomidine dexmedetomidine 0.5 mcg/kgfor 2 min, infusion of propofol as using target controlled infusion pump. Effect site concentration would be changed as the response to i-gel insertion as up and down method in female

Primary Outcome Measures

Name	Time	Method
Concentration of Propofol	from i-gel insertion up to 5 min	effect site concentration of propofol