Diagnosing expiratory flow limitation in COPD patietns with forced oscillation technique using linear regression in the time frequency domai

Conditions: Lung emfysema chronic bronchitis
10038716

Registration Number: NL-OMON29991

Lead Sponsor: Medisch Centrum Alkmaar

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

All patients should meet the standard diagnostic criteria for COPD and they are current or ex-smokers. The subjects must have stable disease at the time of the inclusion, which means that they cannot have an exacerbation of the COPD during the 4 weeks previous to the inclusion

Exclusion Criteria

History of exacerbation of COPD in the preceding month
Upper airway obstruction
Allergic Asthma
OSAS
Extreme obesity (BMI>35)
Pulmonary disease other than COPD
Clinically manifest cardiac disease (for example clinically relevant congestive heart failure, unstable angina pectoris)

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Xrs-8 (cmH20.s/L) (shorthand notation for the most negative value of Xrs during<br /><br>expiration at 8 Hz)<br /><br>Open or closed loop in pressure-volume loop measured by the body<br /><br>plethysmography</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Spirometry: FEV1 (L), FVC (L), IC (L), VC max (L),<br /><br>CO-diffusion: TLCOSB, kCO<br /><br>Body plethysmography: RV (L) TLC (L)<br /><br><br /><br>Forced oscillation technique:<br /><br>Xrs-12,16,20,24 (cmH20.s/L)<br /><br>Rrs-8,12,16,20,24 (cmH20.s/L)<br /><br>Phase-8,12,16,20,24 (degrees)<br /><br>Amplitude-8,12,16,20,24 (cmH20.s/L)<br /><br><br /><br>Other study parameters<br /><br>Anthropometrical data</p><br>