Detection of expiratory flow limitation in COPD patients using within-breath forced oscillation technique during CPAP.

• Conditions: chronic bronchitis; chronic obstructive pulmonary disease; 10006436

• Registration Number: NL-OMON33930
• Lead Sponsor: Medisch Centrum Alkmaar

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Presenting to the outpatient clinic
Age 50-80 years
Diagnosed with COPD according to the standard criteria
Gold Stage II or IV COPD
Current or ex-smokers (at least 10 PY)
Stable disease (No current exacerbation or exacerbation during the 4 weeks previous to the inclusion)

Exclusion Criteria

History of exacerbation of COPD in the preceding month
Upper airway obstruction
Allergic Asthma
OSAS (obstructive sleep apnea syndrome)
Extreme obesity (BMI>30)
Pulmonary disease other than COPD
Clinically manifest cardiac disease (for example clinically relevant congestive heart failure, unstable angina pectoris)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>deltaXrs (cmH20.s/L) at 8 Hz (mid inspiratory minus mid expiratory Xrs) at<br /><br>increasing levels of PEEP</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Negative swing inintrapleural pressure at the beginning of the inspiration<br /><br>measured with an esophageal balloon<br /><br>Variation in bloodpressure during inspiration and exspiration<br /><br>spirometry: IC (L)<br /><br>Xrs-8, 12,16,20,24 (cmH20.s/L) Rrs-8,12,16,20,24 (cmH20.s/L)</p><br>