How alcohol affects the liver and put you on risk of heart diseases?

Completed

Conditions: Other specified symptoms and signsinvolving the circulatory and respiratory systems,

Registration Number: CTRI/2023/11/059450

Lead Sponsor: GBCM and DrKKBM Subharti Medical College

Brief Summary: A prospective cross-sectional study will be planned to be conducted in the dept of Biochemistry of GBCM and Dr. KKBM Subharti Medical Hospital Jhajra Dehradun the study shall be comparing 120 USG confirmed cases of fatty liver attending the OPD as well as IPD of Medicine and Surgey of Hospiatl from july to december 2023.

All over the world alcoholic and non-alcoholioc fatty liver disease are one of the commonest etiology of chronic liver disease. Increased alcohol consumption has held it to increase morbidity, hospital admission, and mortality of alcoholic liver disease. Non-alcoholic fatty liver disease spectrum includes fatty liver, Steatiohepatitis and Cirrhosis. Similarly, ALD spectrum includes simple steatosis, alcoholic hepatitis , combination of alcoholic hepatitis and cirrhosis. alcohol consumption is prevalent all over the world, in Men 40 to 80% of ethanol leads to fatty liver, and 160 gm/day from 10 to 20 years results in hepatitis or liver cirrhosis. only 15% of alcoholics develop alcoholic liver disease. Autonomic dysfunction has been observed in patients with CLD. In most of these studies, autonomic dysfunction has been attributed to an alcoholic-mediated neuropathy, but other liver related mechanisms are conceivable as chronic alcoholism with liver damage has a higher frequency of neuropathy than without it. The Cardiovascular risk is highly evident in alcoholic fatty liver disorder. So we are planning to conduct the study at GBCM and DrKKBM Subharti Hospital.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 120

Inclusion Criteria

Ultrasonographically confirmed patients with fatty liver.

Exclusion Criteria

Age less than 20 and more than 80 Diabetes Mellitus, Hypertension, Confirmed Endocrinopathies.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
primary outcome is risk associated with cardiovascular system in alcoholic hepatitis	at baseline.

Secondary Outcome Measures

Name	Time	Method
Estimation of biochemical parameters in ALD & NALD patients.	Comparison of Lipid profile among ALD & NALD.

Trial Locations

Locations (1): GBCM
🇮🇳
Dehradun, UTTARANCHAL, India
GBCM
🇮🇳Dehradun, UTTARANCHAL, India
Dr Abhinav Manish
Principal investigator
7455074233
abhinav5manish@gmail.com