Exercise in patients with Rheumatoid Arthritis and Cardiovascular risks
- Conditions
- Rheumatoid Arthritis, Cardiovascular disease, Exercise therapy, Inflammation, Cardiorespiratory fitness, Reumatoïde Artritis, Cardiovasculaireziekte, Oefentherapie, Ontsteking,Cardiorespiratoire fitheid
- Registration Number
- NL-OMON26383
- Lead Sponsor
- Reade Center of Rehabilitation and Rheumatology
- Brief Summary
Journals of rheumatology
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Diagnosis of RA fulfilling the ACR/EULAR classification criteria, high 10-year CV risk (≥20%) calculated with the Dutch SCORE table, age >20 and <80 years
Exclusion Criteria
Comorbidity which severely affects functional ability (CIRS≥2), K&L grading of ≥3 for hip and/or knee OA, contra-indication for exercises according to the ACSM guideline (Durnstine 2009) i.e., progressive increase in heart failure symptoms, myocardial infarction less than 3 months before the start of the training program, severe ischemia of the cardiac muscle upon exertion, respiratory frequency of more than 30 breaths per minute and heart rate at rest >110 bpm, insufficient control of the Dutch language and/or cognitive problems.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome of the study is cardiorespiratory fitness assessed with a graded exercise tolerance test on an exercise bike (Lode, the<br>Netherlands).
- Secondary Outcome Measures
Name Time Method Secondary outcomes are functional performance, CV risk factors and disease activity.<br>