Comparison of dexamethasone and clonidine with ropivacaine in adductor canal block for post-operative analgesia in elective knee arthroscopic surgeries
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- 1.To compare postoperative pain using visual analogue scale pain score at 0, 2, 6, 12 and 24 hours at rest
研究概览
简要总结
This randomized, double-blind, parallel-group study compares the efficacy of 0.5% ropivacaine with either dexamethasone versus clonidine as adjuvants for postoperative pain relief in ultrasound-guided adductor canal blocks in patients undergoing elective arthroscopic knee surgery. The primary objectives are to assess postoperative pain using the visual analogue scale at 0, 2, 6, 12, and 24 hours postoperatively, the time to first use of rescue analgesics, and the total rescue analgesic requirement in the first 24 hours. Secondary objectives include evaluating postoperative functional status using the Timed Up and Go test at 24 hours. This study aims to determine which adjuvant provides superior pain control and recovery.The study aims to provide insights into the comparative benefits of dexamethasone and clonidine as adjuvants to enhance the analgesic effects of ropivacaine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •1 Age 18 years to 70 years 2 ASA grade I and II.
- •3 Elective knee arthroscopic surgeries 4 Patients with valid informed consent.
排除标准
- •1 Patients not satisfying inclusion criteria 2 Allergy to local anaesthetics or opioids 3 Local infection, bleeding tendency due to anticoagulant therapy 4 Patient refusal for regional anaesthesia 5 Patients with comorbidities 6 Patient with a previous history of ipsilateral lower limb surgery 7 Substance abuse interfering with pain on the strength of opioids 8 Body mass index greater than 30.
结局指标
主要结局
1.To compare postoperative pain using visual analogue scale pain score at 0, 2, 6, 12 and 24 hours at rest
时间窗: 24 hours postoperatively
2.To compare the time to first rescue analgesic administration.
时间窗: 24 hours postoperatively
3.To compare total rescue analgesic requirement in 24 hours.
时间窗: 24 hours postoperatively
次要结局
- To compare functional status utilizing the TUG (Timed Up and Go) test postoperatively after 24 hours(24 hours postoperatively)
- To compare the time to first rescue analgesic administration.(24 hours postoperatively)
- To compare total rescue analgesic requirement in 24 hours.(24 hours postoperatively)
研究者
Dr B S Siddharth
O P Jindal Institute Of Cancer and Cardiac Research