Local Host Modulating Agents Alendronate & Aloe Vera for Treatment of Furcation Defects in Chronic Periodontitis
- Conditions
- Chronic Periodontitis
- Interventions
- Registration Number
- NCT03204097
- Lead Sponsor
- Government Dental College and Research Institute, Bangalore
- Brief Summary
Alendronate (ALN), commonly use bisphosphonates is proposed to have osteostimulative properties in vivo and in vitro, as shown by an increase in the matrix formation, and acts as a potent inhibitor of bone resorption. AV widely known for its wound healing, analgesic, antioxidant, antibacterial, antiviral, antifungal, immune boosting and significant anti-inflammatory properties. The present study aims to explore the efficacy of 1% ALN and AV gel as a local drug delivery as an adjunct to scaling and root planing (SRP) for the treatment of degree II furcation defects
- Detailed Description
Alendronate (ALN), commonly use bisphosphonates is proposed to have osteostimulative properties in vivo and in vitro, as shown by an increase in the matrix formation, and acts as a potent inhibitor of bone resorption. AV widely known for its wound healing, analgesic, antioxidant, antibacterial, antiviral, antifungal, immune boosting and significant anti-inflammatory properties. The present study aims to explore the efficacy of 1% ALN and AV gel as a local drug delivery as an adjunct to scaling and root planing (SRP) for the treatment of degree II furcation defects.
Methods: Ninety patients with mandibular buccal class II furcation defects were randomly allocated into three treatment groups: SRP plus placebo gel (group 1), SRP plus 1% ALN gel (group 2) and SRP plus AV gel (group3). Clinical and radiographic parameters were recorded at baseline and gel were delivered at respective site. Then again all clinical and radiographic parameters were recorded after 6 and 12 months from baseline.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 90
Systemically healthy patients with mandibular class II furcation defects and asymptomatic endodontically vital mandibular molars with radiolucency in furcation area with PD ≥ 5mm and horizontal PD ≥ 3mm and with no history of antibiotic or any periodontal therapy in past 6 months were included in the study -
Subjects with any known systemic disease, allergic to alendronate or aloe vera, on systemic alendronate therapy, alcoholics, tobacco users, pregnant or lactating women
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description group 1 placebo Scaling and root planing (SRP) followed by placebo gel local drug delivery group 2 Alendronate SRP followed by 1% Alendronate (ALN) gel group 3 Aloe Vera SRP followed by Aloevera (AV) gel
- Primary Outcome Measures
Name Time Method Change in Bone defect depth baseline, 6 & 12 months Assessed in percentage
- Secondary Outcome Measures
Name Time Method Change in modified sulcus bleeding index baseline, 6 & 12 months scale 0-3
Change in relative vertical clinical attachment level baseline, 6 & 12 months measured in mm
Change in pocket probing depth baseline, 6 & 12 months measured in mm
Change in Plaque index baseline, 6 & 12 months scale 0-3
Change in relative horizontal clinical attachment level baseline, 6 & 12 months measured in mm